Q5Y5T5 · ZDHC8_MOUSE
- ProteinPalmitoyltransferase ZDHHC8
- GeneZdhhc8
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids762 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (By similarity).
Could also pamitoylate the D2 dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (By similarity).
Could also play a role in glutamatergic transmission (PubMed:15184899).
Could also pamitoylate the D2 dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (By similarity).
Could also play a role in glutamatergic transmission (PubMed:15184899).
Catalytic activity
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 134 | S-palmitoyl cysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | glutamatergic synapse | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | mitochondrial membrane | |
Cellular Component | mitochondrion | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | postsynapse | |
Molecular Function | palmitoyltransferase activity | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity | |
Biological Process | locomotory behavior | |
Biological Process | peptidyl-L-cysteine S-palmitoylation | |
Biological Process | positive regulation by host of viral process | |
Biological Process | positive regulation of cholesterol efflux | |
Biological Process | regulation of postsynapse assembly |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyltransferase ZDHHC8
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5Y5T5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-13 | Cytoplasmic | ||||
Sequence: MPRSPGTRLKPAK | ||||||
Transmembrane | 14-34 | Helical | ||||
Sequence: YIPVATAAALLVGSSTLFFVF | ||||||
Topological domain | 35-52 | Lumenal | ||||
Sequence: TCPWLTRAVSPAIPVYNG | ||||||
Transmembrane | 53-73 | Helical | ||||
Sequence: ILFLFVLANFSMATFMDPGVF | ||||||
Topological domain | 74-148 | Cytoplasmic | ||||
Sequence: PRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRY | ||||||
Transmembrane | 149-169 | Helical | ||||
Sequence: FFLFLLSLSAHMVGVVAFGLL | ||||||
Topological domain | 170-190 | Lumenal | ||||
Sequence: YVLNHSEGLGAAHTTITMAVM | ||||||
Transmembrane | 191-211 | Helical | ||||
Sequence: CVAGLFFIPVIGLTGFHVVLV | ||||||
Topological domain | 212-762 | Cytoplasmic | ||||
Sequence: TRGRTTNEQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEPPRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKIEAGTFGRDLKTPRPGSAESALSVQRTSPPTPAMYKFRPAFSTGPKTPFCGPNEQVPGPDSLTLADDSTHSLDFVSEPSLDLPDHGPGGLRPPYPPSPPLNTTDAFSGALRSLSLKAASRRGGDHMTLQPLRSEGGPPTPHRSLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGIASYHSPYLHPGPSDPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQTDSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYTGSKAVAFIHTDLPDRQPSLAMQRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNASPARHTLVKKVSGVGGTTYEISV |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice have normal brain morphology, but female have strong locomotor deficits in open field, due to a greater fear of new environments.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 32 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000212878 | 1-762 | Palmitoyltransferase ZDHHC8 | |||
Sequence: MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAIPVYNGILFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLLYVLNHSEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEPPRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKIEAGTFGRDLKTPRPGSAESALSVQRTSPPTPAMYKFRPAFSTGPKTPFCGPNEQVPGPDSLTLADDSTHSLDFVSEPSLDLPDHGPGGLRPPYPPSPPLNTTDAFSGALRSLSLKAASRRGGDHMTLQPLRSEGGPPTPHRSLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGIASYHSPYLHPGPSDPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQTDSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYTGSKAVAFIHTDLPDRQPSLAMQRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNASPARHTLVKKVSGVGGTTYEISV | ||||||
Modified residue | 335 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 439 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 603 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 624 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 672 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 679 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 722 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 740 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain cortex and hippocampus.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 104-154 | DHHC | ||||
Sequence: KWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLL | ||||||
Region | 289-350 | Disordered | ||||
Sequence: GLKAGRSKSKGSLDQLDEKPLDLGPPLPPKIEAGTFGRDLKTPRPGSAESALSVQRTSPPTP | ||||||
Region | 362-423 | Disordered | ||||
Sequence: GPKTPFCGPNEQVPGPDSLTLADDSTHSLDFVSEPSLDLPDHGPGGLRPPYPPSPPLNTTDA | ||||||
Region | 436-537 | Disordered | ||||
Sequence: ASRRGGDHMTLQPLRSEGGPPTPHRSLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGIASYHSPYLHPGPSDPPRPPPRSFSPVLGPRPREPSPVR | ||||||
Compositional bias | 508-531 | Pro residues | ||||
Sequence: HPGPSDPPRPPPRSFSPVLGPRPR | ||||||
Compositional bias | 551-565 | Basic and acidic residues | ||||
Sequence: ERKDREERERLLRSQ | ||||||
Region | 551-574 | Disordered | ||||
Sequence: ERKDREERERLLRSQTDSLFGDSG | ||||||
Compositional bias | 626-657 | Polar residues | ||||
Sequence: SSLSSSMSRAPRTSSSSLQADQANNNAPGPRP | ||||||
Region | 626-684 | Disordered | ||||
Sequence: SSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYTG | ||||||
Region | 707-744 | Disordered | ||||
Sequence: DHPQLKTPPSKLNGQSPGMARLGPAASPMGPNASPARH |
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length762
- Mass (Da)82,031
- Last updated2004-11-23 v1
- Checksum28FC98CACA74B2E8
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A338P749 | A0A338P749_MOUSE | Zdhhc8 | 218 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 508-531 | Pro residues | ||||
Sequence: HPGPSDPPRPPPRSFSPVLGPRPR | ||||||
Compositional bias | 551-565 | Basic and acidic residues | ||||
Sequence: ERKDREERERLLRSQ | ||||||
Compositional bias | 626-657 | Polar residues | ||||
Sequence: SSLSSSMSRAPRTSSSSLQADQANNNAPGPRP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY668947 EMBL· GenBank· DDBJ | AAU89701.1 EMBL· GenBank· DDBJ | mRNA | ||
BC055694 EMBL· GenBank· DDBJ | AAH55694.1 EMBL· GenBank· DDBJ | mRNA |