Q5Y0R1 · Q5Y0R1_9ALPH
- ProteinVirion host shutoff protein
- GeneUL41
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids484 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | virion component | |
Molecular Function | nuclease activity | |
Molecular Function | RNA binding | |
Biological Process | symbiont-mediated degradation of host mRNA | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameVirion host shutoff protein
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus cercopithecinealpha2
Accessions
- Primary accessionQ5Y0R1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Keywords
- Developmental stage
Interaction
Subunit
Interacts with human EIF4H, EIF4A1 and EIF4A2; interaction with eIF4AI and EIF4A2 presumably allows Vhs protein to associate with the eIF4F cap-binding complex.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 109-161 | Disordered | ||||
Sequence: DEEASDLDSSPPGSPISDARSSTAFSNMRRRGHSADAGFWPPPPRPAAPGPGA | ||||||
Compositional bias | 118-137 | Polar residues | ||||
Sequence: SPPGSPISDARSSTAFSNMR | ||||||
Domain | 188-224 | XPG-I | ||||
Sequence: RMEADDACANLYHTNTVAYVHTTDTDLLLMGCDIVLD | ||||||
Region | 274-300 | Disordered | ||||
Sequence: RECGWTPPGQTRGGEGPPRPWRPPSPP | ||||||
Compositional bias | 286-300 | Pro residues | ||||
Sequence: GGEGPPRPWRPPSPP | ||||||
Region | 319-357 | Disordered | ||||
Sequence: DDGDYADEDLAGADRVGPPEEPRGRSPPKARSSSEILTP | ||||||
Compositional bias | 327-346 | Basic and acidic residues | ||||
Sequence: DLAGADRVGPPEEPRGRSPP |
Sequence similarities
Belongs to the herpesviridae VHS protein family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length484
- Mass (Da)54,324
- Last updated2004-11-23 v1
- Checksum5815D8BFD11743B7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 118-137 | Polar residues | ||||
Sequence: SPPGSPISDARSSTAFSNMR | ||||||
Compositional bias | 286-300 | Pro residues | ||||
Sequence: GGEGPPRPWRPPSPP | ||||||
Compositional bias | 327-346 | Basic and acidic residues | ||||
Sequence: DLAGADRVGPPEEPRGRSPP |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY714813 EMBL· GenBank· DDBJ | AAU88107.1 EMBL· GenBank· DDBJ | Genomic DNA |