Q5Y0R1 · Q5Y0R1_9ALPH

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvirion component
Molecular Functionnuclease activity
Molecular FunctionRNA binding
Biological Processsymbiont-mediated degradation of host mRNA
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Virion host shutoff protein

Gene names

    • Name
      UL41

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus cercopithecinealpha2

Accessions

  • Primary accession
    Q5Y0R1

Proteomes

Subcellular Location

Expression

Keywords

Interaction

Subunit

Interacts with human EIF4H, EIF4A1 and EIF4A2; interaction with eIF4AI and EIF4A2 presumably allows Vhs protein to associate with the eIF4F cap-binding complex.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region109-161Disordered
Compositional bias118-137Polar residues
Domain188-224XPG-I
Region274-300Disordered
Compositional bias286-300Pro residues
Region319-357Disordered
Compositional bias327-346Basic and acidic residues

Sequence similarities

Belongs to the herpesviridae VHS protein family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    484
  • Mass (Da)
    54,324
  • Last updated
    2004-11-23 v1
  • Checksum
    5815D8BFD11743B7
MGLFGMMKFAHTHHLIKRRALRAPAGCFTPIAVDLWNVMYTLVLKYQRRYPTYDREAMTLRCLCSLLRVFAQKALYPIFVTDRGVDCTEAAVFGAKAILTHTTAQCRTDEEASDLDSSPPGSPISDARSSTAFSNMRRRGHSADAGFWPPPPRPAAPGPGAKPALKLAHRFCIRVLRALGYAYINSGRMEADDACANLYHTNTVAYVHTTDTDLLLMGCDIVLDISPCYIPTIHCRDLLSYFKMSYPQFLALFVRCHTDLHPDNTQASVDDVLRECGWTPPGQTRGGEGPPRPWRPPSPPVFETRISWTDVLSRQLAGDDGDYADEDLAGADRVGPPEEPRGRSPPKARSSSEILTPPELVTVPDAQLVAEHREYVRRRRRHVLHDAAEAVDWLPEPMTVTELVELRYVKYVISIIAPKRRGPWALLKRLPIYQDPRDEDLARSLVNQHITTPDIAAGFLHQLWTTVPAPPPPYQTVLARFWDE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias118-137Polar residues
Compositional bias286-300Pro residues
Compositional bias327-346Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY714813
EMBL· GenBank· DDBJ
AAU88107.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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