Q5XKE0 · MYPC2_MOUSE
- ProteinMyosin-binding protein C, fast-type
- GeneMybpc2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1136 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoskeleton | |
Cellular Component | myosin filament | |
Molecular Function | actin binding | |
Molecular Function | structural constituent of cytoskeleton | |
Biological Process | cell adhesion | |
Biological Process | muscle contraction |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMyosin-binding protein C, fast-type
- Short namesFast MyBP-C
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5XKE0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000253051 | 1-1136 | Myosin-binding protein C, fast-type | ||
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-39 | Basic and acidic residues | |||
Region | 1-55 | Disordered | |||
Domain | 46-149 | Ig-like C2-type 1 | |||
Compositional bias | 151-165 | Polar residues | |||
Region | 151-177 | Disordered | |||
Domain | 250-339 | Ig-like C2-type 2 | |||
Domain | 340-432 | Ig-like C2-type 3 | |||
Domain | 433-533 | Ig-like C2-type 4 | |||
Domain | 534-633 | Ig-like C2-type 5 | |||
Domain | 636-732 | Fibronectin type-III 1 | |||
Domain | 734-829 | Fibronectin type-III 2 | |||
Domain | 833-927 | Ig-like C2-type 6 | |||
Domain | 930-1025 | Fibronectin type-III 3 | |||
Domain | 1043-1136 | Ig-like C2-type 7 | |||
Sequence similarities
Belongs to the immunoglobulin superfamily. MyBP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,136
- Mass (Da)127,352
- Last updated2004-11-23 v1
- ChecksumD79F73721397DE0D
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A140LI70 | A0A140LI70_MOUSE | Mybpc2 | 155 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-39 | Basic and acidic residues | |||
Compositional bias | 151-165 | Polar residues | |||
Sequence conflict | 619 | in Ref. 2; AAH29762 | |||
Sequence conflict | 648 | in Ref. 1; BAC26371 | |||
Sequence conflict | 900 | in Ref. 1; BAC26371 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK029282 EMBL· GenBank· DDBJ | BAC26371.1 EMBL· GenBank· DDBJ | mRNA | ||
BC029762 EMBL· GenBank· DDBJ | AAH29762.1 EMBL· GenBank· DDBJ | mRNA | ||
BC039184 EMBL· GenBank· DDBJ | AAH39184.1 EMBL· GenBank· DDBJ | mRNA |