Q5XKE0 · MYPC2_MOUSE

  • Protein
    Myosin-binding protein C, fast-type
  • Gene
    Mybpc2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoskeleton
Cellular Componentmyosin filament
Molecular Functionactin binding
Molecular Functionstructural constituent of cytoskeleton
Biological Processcell adhesion
Biological Processmuscle contraction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Myosin-binding protein C, fast-type
  • Short names
    Fast MyBP-C
  • Alternative names
    • C-protein, skeletal muscle fast isoform

Gene names

    • Name
      Mybpc2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • Czech II
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5XKE0
  • Secondary accessions
    • Q8C109
    • Q8K2V0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002530511-1136Myosin-binding protein C, fast-type

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-39Basic and acidic residues
Region1-55Disordered
Domain46-149Ig-like C2-type 1
Compositional bias151-165Polar residues
Region151-177Disordered
Domain250-339Ig-like C2-type 2
Domain340-432Ig-like C2-type 3
Domain433-533Ig-like C2-type 4
Domain534-633Ig-like C2-type 5
Domain636-732Fibronectin type-III 1
Domain734-829Fibronectin type-III 2
Domain833-927Ig-like C2-type 6
Domain930-1025Fibronectin type-III 3
Domain1043-1136Ig-like C2-type 7

Sequence similarities

Belongs to the immunoglobulin superfamily. MyBP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,136
  • Mass (Da)
    127,352
  • Last updated
    2004-11-23 v1
  • Checksum
    D79F73721397DE0D
MPEAKPAAKKASKGKDAPKEAPAKQTPEEPPKEAPPEDQSPTAEEPTGIFLKKPDSVSVETGKDAVILAKVNGKELPGKPTIKWFKGKWQELGSKSGARFIFKESHDSTSNVYTVELHIGKVVLGDRGDYRLEIKAKDVCDSCSFNVDVEAPRQDSSGQSLESFKRSGDGKSEDAGELDFSGLLKKREVVEEEKKKKKDDDDLGIPPEIWELLKGAKKSEYEKIAFQYGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVDRGNKIKLVVEISDPDLPLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVQDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMSVEVSEEGAQVMWMKDGVEMTREDSYKARYRFKKDGKRHILIYSDVAQEDGGRYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKAAEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSDNSIVVVAGNKLRLDVAITGEPPPTATWLRGDEVFTATEGRTHIEQRPDCSSFVIESAERSDEGRYTIKVTNPVGEDVASIFLRVVDVPDPPEAVRVTSVGEDWAILVWEPPKYDGGQPVTGYLMERKKKGSQRWMKINFEVFTDTTYESTKMIEGVLYEMRVFAVNAIGVSQPSMNTKPFMPIAPTSAPQHLTVEDVTDTTTTLKWRPPDRIGAGGIDGYLVEYCLEGSEEWVPANKEPVERCGFTVKDLPTGARILFRVVGVNIAGRSEPATLLQPVTIREIVEQPKIRLPRHLRQTYIRKVGEALNLVIPFQGKPRPQVVWTKGGAPLDTSRVNVRTSDFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPAENVMVKEVWGTNALVEWQPPKDDGNSEITGYFVQKADKKTMEWFNVYEHNRHTSCTVSDLIVGNEYYFRIFSENICGLSDSPGVSKNTARILKTGITLKPLEYKEHDFRTAPKFLTPLMDRVVVAGYTAALNCAVRGHPKPKVVWMKNKMEIHEDPKFLITNYQGILTLNIRRPSPFDAGTYSCRAFNELGEALAECKLDVRVPQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A140LI70A0A140LI70_MOUSEMybpc2155

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias1-39Basic and acidic residues
Compositional bias151-165Polar residues
Sequence conflict619in Ref. 2; AAH29762
Sequence conflict648in Ref. 1; BAC26371
Sequence conflict900in Ref. 1; BAC26371

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK029282
EMBL· GenBank· DDBJ
BAC26371.1
EMBL· GenBank· DDBJ
mRNA
BC029762
EMBL· GenBank· DDBJ
AAH29762.1
EMBL· GenBank· DDBJ
mRNA
BC039184
EMBL· GenBank· DDBJ
AAH39184.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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