Q5XJA4 · Q5XJA4_DANRE
- ProteinAminomethyltransferase
- Geneamt
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids409 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine.
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolate + N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 239 | substrate | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | glycine cleavage complex | |
Cellular Component | mitochondrion | |
Molecular Function | aminomethyltransferase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | transaminase activity | |
Biological Process | glycine catabolic process | |
Biological Process | methylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAminomethyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ5XJA4
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-298 | Aminomethyltransferase folate-binding | ||||
Sequence: LYDFHRAHGGKMVEFAGWSMPVQYKDSHITSHMHTRQHCSIFDVSHMLQTKVYGKDRVKFIESLIVGDIAELKDNQGTLSLFTNSKGGIMDDLIVTKTDQDYLYVVSNAGCADKDSAHMQARLQEFKSAGHDVDLEFMEESLIALQGPSMARVLQKGVGDDLKKLTFMTSVLTPVFGIQGCRVTRCGYTGEDGVEISVPSKDVVLLTEKLLADSEVKLAGLGARDSLRLEAGLCLYGNDIDETTTPVEATLVWT | ||||||
Domain | 325-402 | Glycine cleavage T-protein C-terminal barrel | ||||
Sequence: RKRVGLISTGPPVRQHTPILSSDGRVIGEVTSGCPSPCLKQNVAMGYVETAFSKAGTSIQVEVRKKAVPAVVSKMPFV |
Sequence similarities
Belongs to the GcvT family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length409
- Mass (Da)44,742
- Last updated2004-11-23 v1
- Checksum94E9D4DC9CBF9E99
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC083400 EMBL· GenBank· DDBJ | AAH83400.1 EMBL· GenBank· DDBJ | mRNA | ||
BC164008 EMBL· GenBank· DDBJ | AAI64008.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ104411 EMBL· GenBank· DDBJ | AAZ08415.1 EMBL· GenBank· DDBJ | mRNA |