Q5XIA6 · Q5XIA6_RAT

  • Protein
    Sphingomyelin phosphodiesterase
  • Gene
    Smpd1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Converts sphingomyelin to ceramide.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

162750100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site204Zn2+ 1 (UniProtKB | ChEBI)
Binding site206Zn2+ 1 (UniProtKB | ChEBI)
Binding site276Zn2+ 1 (UniProtKB | ChEBI)
Binding site276Zn2+ 2 (UniProtKB | ChEBI)
Binding site316Zn2+ 2 (UniProtKB | ChEBI)
Binding site423Zn2+ 2 (UniProtKB | ChEBI)
Binding site455Zn2+ 2 (UniProtKB | ChEBI)
Binding site457Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendolysosome
Cellular Componentendosome
Cellular Componentextracellular space
Cellular Componentlamellar body
Cellular Componentlysosome
Cellular Componentplasma membrane
Molecular Functionacid sphingomyelin phosphodiesterase activity
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionsphingomyelin phosphodiesterase activity
Molecular Functionzinc ion binding
Biological Processcellular response to calcium ion
Biological Processcellular response to UV
Biological Processceramide biosynthetic process
Biological Processceramide metabolic process
Biological Processcholesterol metabolic process
Biological Processplasma membrane repair
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of endocytosis
Biological Processpositive regulation of protein dephosphorylation
Biological Processresponse to cocaine
Biological Processresponse to interleukin-1
Biological Processresponse to ionizing radiation
Biological Processresponse to tumor necrosis factor
Biological Processresponse to type I interferon
Biological Processresponse to virus
Biological Processresponse to xenobiotic stimulus
Biological Processsphingomyelin catabolic process
Biological Processsymbiont entry into host cell
Biological Processtermination of signal transduction
Biological Processwound healing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin phosphodiesterase
  • EC number

Gene names

    • Name
      Smpd1
    • ORF names
      rCG_39318

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q5XIA6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-53Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond87↔163
Disulfide bond90↔155
Disulfide bond118↔129
Disulfide bond219↔224
Disulfide bond225↔248
Disulfide bond383↔429
Disulfide bond582↔586
Disulfide bond592↔605

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain83-167Saposin B-type

Sequence similarities

Belongs to the acid sphingomyelinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    627
  • Mass (Da)
    69,761
  • Last updated
    2004-11-23 v1
  • Checksum
    2BE1585CF13F454C
MPHHGASSGQGHLRAGWEQRLERSLPAPKLGLLWMGLGLALVLALFDSTVLWVPARAYPLPSQGHSVKFSAVAPQLQNAFGWRNLTCPACKVLFTALNYGLKKEPNVARVGSVAIKMCKMLNIAPLNVCQSAVHLFEDDVVDVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHDYLEGTDPNCADPLCCRRGSGWPPNSRTGAGYWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALNTITDLVWKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVDELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLGPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAPGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRADEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDAHSLWSRPLLC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC083780
EMBL· GenBank· DDBJ
AAH83780.1
EMBL· GenBank· DDBJ
mRNA
CH473956
EMBL· GenBank· DDBJ
EDM18044.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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