Q5XI33 · CIDEC_RAT

  • Protein
    Lipid transferase CIDEC
  • Gene
    Cidec
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (By similarity).
Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (By similarity).
Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity).
The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity).
Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (By similarity).
May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (PubMed:23233732).
When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (By similarity).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentlipid droplet
Cellular Componentnucleus
Molecular Functionlipid transfer activity
Molecular Functionmolecular condensate scaffold activity
Molecular Functionphosphatidic acid binding
Molecular Functionphosphatidylinositol binding
Molecular Functionphosphatidylserine binding
Biological Processapoptotic process
Biological Processexecution phase of apoptosis
Biological Processlipid droplet fusion
Biological Processlipid droplet organization
Biological Processlipid storage
Biological Processnegative regulation of lipid catabolic process
Biological Processnegative regulation of triglyceride metabolic process
Biological Processregulation of apoptotic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipid transferase CIDEC
  • Alternative names
    • Cell death-inducing DFFA-like effector protein C
    • Fat-specific protein FSP27

Gene names

    • Name
      Cidec
    • Synonyms
      Fsp27

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q5XI33

Proteomes

Organism-specific databases

Subcellular Location

Lipid droplet
Endoplasmic reticulum
Nucleus
Note: Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004197211-238Lipid transferase CIDEC

Post-translational modification

Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life (about 15 minutes in 3T3-L1 cells). Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation.

Keywords

Proteomic databases

PTM databases

Expression

Induction

Down-regulated upon hypertonic conditions.

Gene expression databases

Interaction

Subunit

Homodimer (By similarity).
Interacts with CIDEA (By similarity).
Homooligomer; undergoes liquid-liquid phase separation (LLPS) via its N-terminus, facilitating lipid droplet fusion, occurs at the lipid droplet contact sites (By similarity).
Interacts with PLIN1 (By similarity).
Interacts with NFAT5; this interaction is direct and retains NFAT5 in the cytoplasm (PubMed:23233732).
Interacts with CEBPB (By similarity).
Interacts with isoform CLSTN3beta of CLSTN3; inhibiting the lipid transferase activity of CIDEC (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-35Required for liquid-liquid phase separation (LLPS)
Domain41-118CIDE-N

Domain

The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer.

Sequence similarities

Belongs to the CIDE family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    238
  • Mass (Da)
    27,214
  • Last updated
    2004-11-23 v1
  • Checksum
    E6489A38F1CA5277
MDYAMKSLSLLYPRSLSRHVAVSTAVVTQQLVSEPSRETPRARPCRVSTADRKVRKGIMAHSLEDLLGKVQDILKLKDKPFSLVLEEDGTIVETEEYFQALPRDTVFMVLQKGQKWKSPSEQRKKKAQLSLSQKPTKKIDVARVTFDLYKLNPQDFIGCLNVKATLYDTYSLSYDLHCYRAKRIVKEMLRWTLFSMQATGHMLLGTSSYMQQFLDATEEEQPSKAKASLLPACLKMLQ

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2K551A0A0G2K551_RATCidec248
A0A8I6AQV9A0A8I6AQV9_RATCidec261
A0A8I6A975A0A8I6A975_RATCidec254
A0A8I6GGI9A0A8I6GGI9_RATCidec239

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC083860
EMBL· GenBank· DDBJ
AAH83860.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp