Q5XFN2 · DESM_CANLF

Function

function

Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity).
Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin

Features

Showing features for site.

146950100150200250300350400450
TypeIDPosition(s)Description
Site353Stutter

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell tip
Cellular Componentcell-cell junction
Cellular Componentcytoplasm
Cellular Componentintercalated disc
Cellular Componentintermediate filament
Cellular Componentnuclear envelope
Cellular Componentnucleus
Cellular Componentsarcolemma
Cellular ComponentZ disc
Biological Processintermediate filament organization
Biological Processnuclear envelope organization
Biological Processskeletal muscle organ development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Desmin

Gene names

    • Name
      DES

Organism names

Accessions

  • Primary accession
    Q5XFN2

Proteomes

Subcellular Location

Cytoplasm
Nucleus
Cell tip
Nucleus envelope
Note: Localizes in the intercalated disks which occur at the Z line of cardiomyocytes. Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes. PKP2 is required for correct anchoring of DES at the cell tip and nuclear envelope (By similarity).

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00000637702-469Desmin
Modified residue7Phosphoserine; by CDK1
Modified residue12Phosphoserine; by AURKB
Modified residue16Omega-N-methylarginine
Modified residue17Phosphothreonine; by AURKB and ROCK1
Modified residue28Phosphoserine; by CDK1
Modified residue32Phosphoserine; by CDK1
Modified residue37Asymmetric dimethylarginine; alternate
Modified residue37Omega-N-methylarginine; alternate
Modified residue45Phosphoserine
Modified residue58ADP-ribosylarginine
Modified residue60Phosphoserine; by AURKB
Modified residue70Omega-N-methylarginine
Modified residue76Phosphothreonine; by ROCK1
Modified residue81Phosphoserine
Modified residue289Phosphoserine
Modified residue357Phosphoserine
Modified residue360Phosphoserine
Modified residue423Phosphoserine

Post-translational modification

ADP-ribosylation prevents ability to form intermediate filaments.
Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1, phosphorylation at Ser-60 by AURKB and phosphorylation at Thr-76 by ROCK1 contribute to efficient separation of desmin intermediate filaments during mitosis.
Ubiquitination by a SCF-like complex containing ASB2 leads to proteasomal degradation.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homomer (PubMed:24413773).
Interacts with DST (By similarity).
Interacts with MTM1 (By similarity).
Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (By similarity).
Interacts with CRYAB (By similarity).
Interacts with NEB (via nebulin repeats 160-164) (By similarity).
Interacts (via rod region) with NEBL (via nebulin repeats 1-5) (By similarity).
Interacts with ASB2; the interaction targets DES for proteasomal degradation (By similarity).
Interacts with PKP1 (By similarity).
Interacts with FLII (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region2-107Head
Domain107-415IF rod
Region108-140Coil 1A
Region141-150Linker 1
Region151-251Coil 1B
Region252-267Linker 12
Region267-414Interaction with NEB
Region268-286Coil 2A
Region287-294Linker 2
Region295-411Coil 2B
Region412-469Tail
Region437-452Interaction with CRYAB

Sequence similarities

Belongs to the intermediate filament family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    53,321
  • Last updated
    2007-01-23 v3
  • Checksum
    55A18E42D6D6C31B
MSQAYSSSQRVSSYRRTFGGAGGFPLGSPLGSPVFPRAGFGTKGSSSSVTSRVYQVSRTSGGAGGLGALRAGRLGTGRAPSYSAGELLDFSLADAVNQEFLTTRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAEIYEEELRELRRQVEVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMREMEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTYSALNFRETSPEQRGSEVHTKKTVMIKTIETRDGEVVSEATQQQHEVL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BK005142
EMBL· GenBank· DDBJ
DAA05325.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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