Q5WWN6 · Q5WWN6_LEGPL

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • Ordered locus names
      lpl1416

Organism names

Accessions

  • Primary accession
    Q5WWN6

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical
Transmembrane52-74Helical
Transmembrane81-98Helical
Transmembrane104-128Helical
Transmembrane135-155Helical
Transmembrane167-191Helical
Transmembrane223-241Helical
Transmembrane261-278Helical
Transmembrane290-308Helical
Transmembrane314-337Helical
Transmembrane344-371Helical
Transmembrane383-402Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-406Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    429
  • Mass (Da)
    47,386
  • Last updated
    2004-11-23 v1
  • MD5 Checksum
    D6680FEB5A3029A9664BB7AF01DA5B2F
MSLENKISLKGLLVWLICALFFMYEFLLRTVVGTFQTQLVNDLNLTPMTFSLLSSTGYLVIYGIMQIPVGIIAARFGLKKALFIALVFCASSTMGFALSHHFGIAMFCRIVMGLGSSFGFICLLISVYDWMPRKNIALFIGISQFIGTLGPMLAAGPLNSLSQNSMIGWRGIFLSMAIIGMIIAALTLLFVENNRNNREKFIVLTKPVKISLSLQKLMSHKQVWSIALFSGCVYFSIEYFSENMGVEFLIKKGFSPMYSSYMITLAWLGYALGCPLFGFISDKIHRRKPVMLTSAFAAWLSLSGIIYFSFGEVLTGFCFFTLGLSASGQSIGFAAIAEQCKENYLAIGLAFNNTMIAIITSVSAPIIGGMLSYPAQIKNYQEALFVLIIFSIISVIISAFMIKETFGKSVRENTILSFDSTNRSGNLYC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR628337
EMBL· GenBank· DDBJ
CAH15656.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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