Q5WGP6 · Q5WGP6_SHOC1
- ProteinGlucose-6-phosphate 1-dehydrogenase
- Genezwf
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + H+ + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 15-22 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GSTGDLAK | ||||||
Binding site | 49 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 90-91 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: DV | ||||||
Binding site | 153 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 183 | substrate | ||||
Sequence: H | ||||||
Binding site | 187 | substrate | ||||
Sequence: K | ||||||
Binding site | 221 | substrate | ||||
Sequence: E | ||||||
Binding site | 240 | substrate | ||||
Sequence: D | ||||||
Active site | 245 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 345 | substrate | ||||
Sequence: K | ||||||
Binding site | 350 | substrate | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
- Short namesG6PD
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Shouchella
Accessions
- Primary accessionQ5WGP6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-192 | Glucose-6-phosphate dehydrogenase NAD-binding | ||||
Sequence: VIFGSTGDLAKRKLFPSIYNLYRKGNLNEHFAVVGLGRREWDDEKLRTVVMESIQEELGEQRPEVTESFLKHFSYLSFDVTNKDSYSELNDKLHILDETFQIPGNRIFYMAMAPEFFGQIAQSIHNEGLKDTQGWTRLVIEKPFGTDLQSAIRLNDEIRQAFSEDEIYRIDHYLGKEMVQN | ||||||
Domain | 195-490 | Glucose-6-phosphate dehydrogenase C-terminal | ||||
Sequence: VIRFANAIFGSLWNNRHIANIQVTSSEQLGVEGRGGYYEKSGALRDMVQNHMLQMVSLLAMDVPLRLSTDDIRSEKIKVLRALRPIVGESIKENVVRGQYGRGEINGQEVIGYLEEENVSDSSKTETYVAAKLMIDNHVWAGVPFYIRTGKRMAVKSTKIVVEFKELPLNLYSKENKQTGPNLLIIHIQPDEGMTIVLNGKKIGSADTTPVHLQYRHDSEDRFNTPEAYERLLFDCMMGDATNFAHWDEVSLSWSLVDAISKAWSESGEKLPTYRAGSMGPKEADELLEADGFSWW |
Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)56,528
- Last updated2004-11-23 v1
- ChecksumE5FDBB0316AC2F7B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP006627 EMBL· GenBank· DDBJ | BAD64459.1 EMBL· GenBank· DDBJ | Genomic DNA |