Q5WEW8 · ARGJ_SHOC1

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site124Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site125Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site158substrate
Binding site184substrate
Site194-195Cleavage; by autolysis
Active site195Nucleophile
Binding site195substrate
Binding site281substrate
Binding site403substrate
Binding site408substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Molecular Functionmethione N-acyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • Ordered locus names
      ABC2557

Organism names

Accessions

  • Primary accession
    Q5WEW8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000021171-194Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_0000002118195-408Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    408
  • Mass (Da)
    42,826
  • Last updated
    2004-11-23 v1
  • Checksum
    45C55C81659F1AEB
MLTKQTTGQAWKQIKGSITDVKGFTTAGAHCGLKRKRLDIGAIFCDVPANAAGVFTLNQIQAAPLKVTKESLAHSNGKLQAVLVNSGNANACTGASGLVDAYEMRALAAAKFAVPEEMVAVTSTGVIGEKMPMEKVRSGIEDLVLSKESTPFAEAILTTDTGTKEVCVEVVIDQKTVRIAGVAKGSGMIHPNMATMLGFITTDANIETAALKRALAKATDETFNRITVDGDTSTNDMVLVLASGLADNQPLDETHPDWANFYGALSACAESLAKKIAKDGEGATKLIEVQVAGAVSDEEAGKVAKAIVGSDLVKTAAYGKDGNWGRIICAIGYSGCTLDPDTIDIAIGPYETLVQSEPVVVDDAAISKYMEAETIVIKADLHQGQGVGKAWGCDLTYDYVRINAGYRT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP006627
EMBL· GenBank· DDBJ
BAD65092.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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