Q5W6F1 · TCMO_ORYSJ
- ProteinTrans-cinnamate 4-monooxygenase
- GeneC4HL
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids500 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the first oxidative step of the phenylpropanoid pathway in higher plants by transforming trans-cinnamate into p-coumarate (By similarity).
The compounds formed by this pathway are essential components for lignification, pollination, and defense against ultraviolet light, predators and pathogens (By similarity).
The compounds formed by this pathway are essential components for lignification, pollination, and defense against ultraviolet light, predators and pathogens (By similarity).
Catalytic activity
- (E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] = (E)-4-coumarate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]This reaction proceeds in the forward direction.
Cofactor
Pathway
Phenylpropanoid metabolism; trans-4-coumarate biosynthesis; trans-4-coumarate from trans-cinnamate: step 1/1.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | trans-cinnamate 4-monooxygenase activity | |
Biological Process | lignin metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTrans-cinnamate 4-monooxygenase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ5W6F1
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 3-23 | Helical | ||||
Sequence: ALLVEKVLLGLFVAAVLALVV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000451426 | 1-500 | UniProt | Trans-cinnamate 4-monooxygenase | |||
Sequence: MDALLVEKVLLGLFVAAVLALVVAKLTGKRLRLPPGPAGAPIVGNWLQVGDDLNHRNLMALARRFGDILLLRMGVRNLVVVSSPDLAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGDHWRKMRRIMTVPFFTNKVVAQNRAGWEEEARLVVEDVRRDPAAATSGVVIRRRLQLMMYNDMFRIMFDRRFDSVDDPLFNKLKAFNAERSRLSQSFEYNYGDFIPVLRPFLRRYLARCHQLKSQRMKLFEDHFVQERKRVMEQTGEIRCAMDHILEAERKGEINHDNVLYIVENINVAAIETTLWSIEWGIAELVNHPSIQSKVREEMASVLGGAAVTEPDLERLPYLQAVVKETLRLRMAIPLLVPHMNLADGKLAGYDIPAESKILVNAWFLANDPKRWVRPDEFRPERFLEEEKAVEAHGNDFRFVPFGVGRRSCPGIILALPIIGITLGRLVQSFDLLPPPGMDKVDTTEKPGQFSNQILKHATVVCKPIDA | |||||||
Modified residue (large scale data) | 134 | PTMeXchange | Phosphothreonine | ||||
Sequence: T |
Proteomic databases
Expression
Tissue specificity
Expressed in roots and leaves.
Induction
Induced by wounding.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length500
- Mass (Da)56,883
- Last updated2004-12-07 v1
- ChecksumFD4242B9BE859870
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB207105 EMBL· GenBank· DDBJ | BAF45113.1 EMBL· GenBank· DDBJ | mRNA | ||
AC136224 EMBL· GenBank· DDBJ | AAV44089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008211 EMBL· GenBank· DDBJ | BAF17104.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014961 EMBL· GenBank· DDBJ | BAS93361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000142 EMBL· GenBank· DDBJ | EEE63250.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK100598 EMBL· GenBank· DDBJ | BAG94673.1 EMBL· GenBank· DDBJ | mRNA | ||
AK104994 EMBL· GenBank· DDBJ | BAG97065.1 EMBL· GenBank· DDBJ | mRNA |