MFC adds significant information on dyspoiesis in the diagnostic work up for MDS and provides prognostic information. MNDA expression can be assessed by MFC and may facilitate evaluation of dyspoiesis when added to MDS MFC panels.
these data support the inclusion of MNDA in the diagnostic evaluation of extramedullary B-cell lymphomas particularly those in which the differential diagnosis is between low-grade follicular lymphoma and marginal zone lymphoma.
Myeloid antigen expression is a predictor of a poor response to chemotherapy and an adverse prognostic factor in adult T-lymphoblastic lymphoma but not in children with T-LBL.
MNDA has a role regulating programmed cell death in myeloid progenitor cells and that its down-regulation in myelodysplastic syndromes is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death.
variation in MNDA expression appeared to change with phenotypic specialization of monocytes in atherosclerosis consistent with its association with inflammation and suspected roles in regulating gene expression or in mediating cell death
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