Q5VJS5 · DAAF4_RAT

  • Protein
    Dynein axonemal assembly factor 4
  • Gene
    Dnaaf4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentdynein axonemal particle
Cellular Componentextracellular region
Cellular Componentneuron projection
Cellular Componentnon-motile cilium
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionnuclear estrogen receptor binding
Biological Processcilium movement
Biological Processdetermination of left/right symmetry
Biological Processepithelial cilium movement involved in extracellular fluid movement
Biological Processestablishment of localization in cell
Biological Processheart development
Biological Processinner dynein arm assembly
Biological Processlearning or memory
Biological Processneuron migration
Biological Processouter dynein arm assembly
Biological Processregulation of intracellular estrogen receptor signaling pathway
Biological Processregulation of proteasomal protein catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Dynein axonemal assembly factor 4
  • Alternative names
    • Dyslexia susceptibility 1 candidate gene 1 protein homolog

Gene names

    • Name
      Dnaaf4
    • Synonyms
      Dyx1c1, Ekn1

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q5VJS5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004034801-420Dynein axonemal assembly factor 4

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with ZMYND10 (By similarity).
Interacts with STUB1 (By similarity).
Interacts with ESR1 and ESR2. Interacts with DNAAF2 (By similarity).
Interacts with CCT3, CCT4, CCT5 and CCT8 (By similarity).
Interacts with DNAAF6/PIH1D3 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

TypeIDPosition(s)Description
Domain3-87CS
Region7-103Mediates interaction with ESR1 and STUB1
Compositional bias165-187Basic and acidic residues
Region165-212Disordered
Repeat288-321TPR 1
Repeat323-355TPR 2
Repeat364-397TPR 3

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    48,119
  • Last updated
    2004-12-07 v1
  • Checksum
    0DA24EBCB50EA32A
MPVRVSEFSWQQTPAALFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFEVFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWESLSMPGVDKEMMQRIREKSILQAQEKAKEATEAKAAAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATRELEAWKECQKKADGQKRVQRKEKPLQGKQAEERGALKPQSLPRKAPPTRLPTRGRNWENIFSEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFSDLKEEEKNPDWLKDKGNKLFATENYLAAIDAYNLAIRLNRKIPVLYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQGTTLKSHD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AHU0A0A8I6AHU0_RATDnaaf4413

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias165-187Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY428506
EMBL· GenBank· DDBJ
AAR89524.1
EMBL· GenBank· DDBJ
mRNA
BC085838
EMBL· GenBank· DDBJ
AAH85838.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp