Q5VAL8 · Q5VAL8_9ENTO

  • Protein
    Genome polyprotein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of immature procapsids, which is cleaved into capsid proteins VP4 and VP2 after maturation. Allows the capsid to remain inactive before the maturation step.
Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome.
Lies on the inner surface of the capsid shell. After binding to the host receptor, the capsid undergoes conformational changes. Capsid protein VP4 is released, Capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentviral capsid
Molecular Functionstructural molecule activity
Biological Processsymbiont genome entry into host cell via pore formation in plasma membrane
Biological Processsymbiont-mediated suppression of host gene expression
Biological Processvirion attachment to host cell

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BAN00-10217
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Picornaviridae > Ensavirinae > Enterovirus > Enterovirus B

Accessions

  • Primary accession
    Q5VAL8

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts with capsid protein VP1 and capsid protein VP3 to form heterotrimeric protomers.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-20Disordered
Domain93-299Picornavirus capsid
Domain358-524Picornavirus capsid
Domain608-777Picornavirus capsid

Sequence similarities

Belongs to the picornaviruses polyprotein family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    854
  • Mass (Da)
    94,983
  • Last updated
    2004-12-07 v1
  • Checksum
    6F41A6C152CDC9BB
MGAQVSTQKTGAHETGLSASNGASIHYTNINYYSDSASRSSNRQDFAQDPGKFTEPVKDIMIKSLPALNSPSAEECGYSDRVRSITLGNSTITTQEGANVVVAYGEWPQYLSDKEATAEDQPTQPDVATCRFYTLESVQWQENSRGWWWKFPEMLKDMGLFGQNMHYHYLGRAGYTIHVQCNASKFHQGCLLVVCVPEAEMGSATVGQAFDFTALTNQDTPHQFTEGASTGKMVQTAVCNAGMGVGVGNLTIFPHQWINLRTNNSATIVMPYINSVPMDNMFRHYNFTLMIIPFAPLAYSTGATTYVPITVTIAPMFAEYNGLRLGSTQGLPVMATPGSNQFLTSDNFQSPSAMPQFDVTPEMHIPGEVRNLMEIAEVDSVMPINNTTGKCDKMDAYQIEVNAGNTNTTTAIFSFQVDPGYSTVLNRTLMGEMLNYYAHWSGSMKLTFLFCGSAMATGKLLLAYSPPGASVPTSRKQAMLGTHIIWDLGLQSSCVLCIPWISQSHYRMVHKDPYTAAGYVTCWYQTNIVVPADTPQKCVVLGFASACNDFSVRLLRDTPFIEQKTQLQGDEHDSHVANTEATGPTNSMQVPALTAVETGHTSQVVPGDTIQTRHVVNFHSRSESTLENFMGRAACVFLSTYQSMDTSDKTKRYTNWDINIREMVQLRRKCELFTYMRFDIEVTFVITSRQDPGTNLEQDMPVLTHQIMYIPPGGPIPEEVSSYAWQTSTNPSVFWTEGNAPARMSIPFISVGNAYSTFYDGWSHFSQTGVYGYTTLNSMGKLYIRHVNASTPTQITSTVRVYFKPKHVRAWVPRPPRLCQYKTKASVDFEVTKVTEERESINTVPKVDHSFQTY

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue854

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY556059
EMBL· GenBank· DDBJ
AAT65953.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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