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Q5UUD7 · Q5UUD7_MACRS

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • UMDB202
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Caridea > Palaemonoidea > Palaemonidae > Macrobrachium

Accessions

  • Primary accession
    Q5UUD7
  • Secondary accessions
    • E2DHC8

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-45Helical
Transmembrane66-90Helical
Transmembrane110-133Helical
Transmembrane145-172Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-200Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    200
  • Mass (Da)
    21,448
  • Last updated
    2004-12-07 v1
  • MD5 Checksum
    3480714A701DBD7082DE1F9E35D4CC9F
AELGQPGSLIGNDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLSSGMVESGVGTGWTVYPPLAAGTAHAGASVDLGIFSLHLAGVSSILGAVNFITTVINMRAPGMTMDRLPLFVWAVFLTAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue200

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY554294
EMBL· GenBank· DDBJ
AAT48950.1
EMBL· GenBank· DDBJ
Genomic DNA
AY614547
EMBL· GenBank· DDBJ
AAU43227.1
EMBL· GenBank· DDBJ
Genomic DNA
AY614548
EMBL· GenBank· DDBJ
AAU43228.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ060194
EMBL· GenBank· DDBJ
AAZ08397.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ995505
EMBL· GenBank· DDBJ
ADK55088.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ995506
EMBL· GenBank· DDBJ
ADK55089.1
EMBL· GenBank· DDBJ
Genomic DNA
KF499324
EMBL· GenBank· DDBJ
AGU38112.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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