Q5U676 · Q5U676_HUMAN
- ProteinGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- GeneB3GAT3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids341 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H+ + UDP
Cofactor
Pathway
Protein modification; protein glycosylation.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 88-90 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: PTY | ||||||
Binding site | 119 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 162 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 167 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 200-202 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: DDD | ||||||
Binding site | 202 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 233 | Interaction with galactose moiety of substrate glycoprotein | ||||
Sequence: E | ||||||
Active site | 287 | Proton donor/acceptor | ||||
Sequence: E | ||||||
Binding site | 314-316 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: HTR | ||||||
Site | 324 | Interaction with galactose moiety of substrate glycoprotein | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi membrane | |
Molecular Function | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | |
Molecular Function | metal ion binding | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ5U676
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Single-pass type II membrane protein
Keywords
- Cellular component
Disease & Variants
Organism-specific databases
PTM/Processing
Features
Showing features for disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 39 | Interchain | ||||
Sequence: C | ||||||
Glycosylation | 306 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length341
- Mass (Da)37,828
- Last updated2004-12-07 v1
- Checksum130B8EDDBB67DE88
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: L |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC019832 EMBL· GenBank· DDBJ | AAH19832.1 EMBL· GenBank· DDBJ | mRNA |