Q5U415 · Q5U415_MOUSE
- ProteinAldo-keto reductase family 1 member B1
- GeneAkr1b1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids316 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- (E)-hex-2-en-1-ol + NADP+ = (E)-hex-2-enal + H+ + NADPH
- (E,E)-2,4-hexadien-1-ol + NADP+ = (E,E)-2,4-hexadienal + H+ + NADPH
- 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP+
- 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H+ + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP+
- 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP+
- 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP+
- 13-cis-retinol + NADP+ = 13-cis-retinal + H+ + NADPH
- 9-cis-retinol + NADP+ = 9-cis-retinal + H+ + NADPH
- NADP+ + prenol = 3-methyl-2-butenal + H+ + NADPH
- NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin H2
- a 4-hydroxynonen-1-ol + NADP+ = a 4-hydroxynonenal + H+ + NADPH
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 49 | Proton donor | ||||
Sequence: Y | ||||||
Site | 78 | Lowers pKa of active site Tyr | ||||
Sequence: K | ||||||
Binding site | 111 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | oxidoreductase activity |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldo-keto reductase family 1 member B1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5U415
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-289 | NADP-dependent oxidoreductase | ||||
Sequence: LGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFELSSEDMATL |
Sequence similarities
Belongs to the aldo/keto reductase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length316
- Mass (Da)35,746
- Last updated2005-05-10 v1
- ChecksumE18759B9A940AA0E