Q5U415 · Q5U415_MOUSE

  • Protein
    Aldo-keto reductase family 1 member B1
  • Gene
    Akr1b1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Catalytic activity

  • (E)-hex-2-en-1-ol + NADP+ = (E)-hex-2-enal + H+ + NADPH
  • (E,E)-2,4-hexadien-1-ol + NADP+ = (E,E)-2,4-hexadienal + H+ + NADPH
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H+ + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP+
  • 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 13-cis-retinol + NADP+ = 13-cis-retinal + H+ + NADPH
  • 9-cis-retinol + NADP+ = 9-cis-retinal + H+ + NADPH
  • NADP+ + prenol = 3-methyl-2-butenal + H+ + NADPH
  • NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin H2
  • a 4-hydroxynonen-1-ol + NADP+ = a 4-hydroxynonenal + H+ + NADPH
  • all-trans-retinol + NADP+ = all-trans-retinal + H+ + NADPH
    EC:1.1.1.300 (UniProtKB | ENZYME | Rhea)
  • an alditol + NADP+ = an aldose + H+ + NADPH
    EC:1.1.1.21 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site, site, binding site.

TypeIDPosition(s)Description
Active site49Proton donor
Site78Lowers pKa of active site Tyr
Binding site111substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionoxidoreductase activity

Keywords

  • Ligand
    • #NADP

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldo-keto reductase family 1 member B1
  • EC number
  • Alternative names
    • Aldose reductase

Gene names

    • Name
      Akr1b1
    • Synonyms
      Akr1b3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FVB/N-3
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5U415

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-289NADP-dependent oxidoreductase

Sequence similarities

Belongs to the aldo/keto reductase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    316
  • Mass (Da)
    35,746
  • Last updated
    2005-05-10 v1
  • Checksum
    E18759B9A940AA0E
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFELSSEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC085310
EMBL· GenBank· DDBJ
AAH85310.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp