TATA-box binding protein O-GlcNAcylation at T114 regulates formation of BTAF1-TFIID complex and is critical for the genetic regulation of energy metabolism.
Study findings demonstrate TBP as mechanism of host-response activation by HIV-1 Tat and suggest that promoter plasticity is a challenge imposed by co-morbid factors such as stimulant drug addiction.
In an integrative approach combining crystal coordinates biochemical analyses and data from cross-linking mass-spectrometry (CLMS) the authors determine the architecture of the TAF11/TAF13/TBP complex revealing TAF11/TAF13 interaction with the DNA binding surface of TBP.
we observed that carriers of either ATXN7 or TBP alleles with relatively large CAG repeat sizes in both alleles had a substantially increased risk of lifetime depression.
these studies support the idea that increases in TBP expression contribute to enhanced VEGFA transcription early in colorectal cancer development to drive tumorigenesis.
The genetic animal models of SCA17 clearly indicate that the phenotypes are dependent on the expression levels of mutant TBP and the length of CAG/glutamine repeat.
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