Q5TZE1 · BTB6B_DANRE

Function

function

Adapter protein for the cul3 E3 ubiquitin-protein ligase complex. Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation. Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Biological Processneurogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    BTB/POZ domain-containing protein 6-B

Gene names

    • Name
      btbd6b
    • Synonyms
      btbd6
    • ORF names
      si:dkey-11b8.2

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q5TZE1

Proteomes

    • Identifier
    • Component
      Alternate scaffold 20, Chromosome 20

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Present mainly, but not excusively in the cytoplasm.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003802481-482BTB/POZ domain-containing protein 6-B

Proteomic databases

Expression

Tissue specificity

In embryos, expressed in the cranial ganglia.

Gene expression databases

Interaction

Subunit

Interacts with cul3. Interacts (via BTB domain) with zbtb16/plzf (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain80-150BTB

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    482
  • Mass (Da)
    53,273
  • Last updated
    2004-12-07 v1
  • Checksum
    95F9B2F98DCF7F2B
MAAELYPASINTNLPNSNSTAVTAASKKTIVQVTQTVTTPTTTATQQNINNNNVETASWQSTHPTLRERNALMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKRQGLGPTARNKRAVLGKALYLVRIPTMTLEEFANGAAQSDVLTLEETHDVFLWYTAANKPKLEFPLQKRKGLTPQRCHRFQSSAYRSNQWRYRGRCDSIQFAVDKRIFIAGLGLYGSSGGKAEYSVKIELKRQGVTLAQNLTKFISDGSSNTFSVWFEHPVQVEQDTFYTVSAVLDGNELSYFGQEGMTEVQCGKVTFQFQCSSDSTNGTGVQGGQIPELVFYA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M2B7L0A0A8M2B7L0_DANREbtbd6b535

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX255905
EMBL· GenBank· DDBJ
CAH68989.1
EMBL· GenBank· DDBJ
Genomic DNA
BX321888
EMBL· GenBank· DDBJ
CAK11390.1
EMBL· GenBank· DDBJ
Genomic DNA
BC124114
EMBL· GenBank· DDBJ
AAI24115.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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