Q5TZE1 · BTB6B_DANRE
- ProteinBTB/POZ domain-containing protein 6-B
- Genebtbd6b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids482 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Adapter protein for the cul3 E3 ubiquitin-protein ligase complex. Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation. Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Biological Process | neurogenesis |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBTB/POZ domain-containing protein 6-B
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ5TZE1
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000380248 | 1-482 | BTB/POZ domain-containing protein 6-B | |||
Sequence: MAAELYPASINTNLPNSNSTAVTAASKKTIVQVTQTVTTPTTTATQQNINNNNVETASWQSTHPTLRERNALMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKRQGLGPTARNKRAVLGKALYLVRIPTMTLEEFANGAAQSDVLTLEETHDVFLWYTAANKPKLEFPLQKRKGLTPQRCHRFQSSAYRSNQWRYRGRCDSIQFAVDKRIFIAGLGLYGSSGGKAEYSVKIELKRQGVTLAQNLTKFISDGSSNTFSVWFEHPVQVEQDTFYTVSAVLDGNELSYFGQEGMTEVQCGKVTFQFQCSSDSTNGTGVQGGQIPELVFYA |
Proteomic databases
Expression
Tissue specificity
In embryos, expressed in the cranial ganglia.
Gene expression databases
Interaction
Subunit
Interacts with cul3. Interacts (via BTB domain) with zbtb16/plzf (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 80-150 | BTB | ||||
Sequence: ADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEA |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length482
- Mass (Da)53,273
- Last updated2004-12-07 v1
- Checksum95F9B2F98DCF7F2B
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2B7L0 | A0A8M2B7L0_DANRE | btbd6b | 535 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX255905 EMBL· GenBank· DDBJ | CAH68989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX321888 EMBL· GenBank· DDBJ | CAK11390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC124114 EMBL· GenBank· DDBJ | AAI24115.1 EMBL· GenBank· DDBJ | mRNA |