Q5TZ66 · SN25A_DANRE
- ProteinSynaptosomal-associated protein 25-A
- Genesnap25a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids204 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Cellular Component | neuron projection | |
Cellular Component | plasma membrane | |
Cellular Component | presynapse | |
Cellular Component | SNARE complex | |
Cellular Component | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex | |
Molecular Function | SNAP receptor activity | |
Molecular Function | syntaxin-1 binding | |
Molecular Function | voltage-gated potassium channel activity | |
Biological Process | exocytosis | |
Biological Process | locomotory behavior | |
Biological Process | mitotic cytokinesis | |
Biological Process | synaptic vesicle fusion to presynaptic active zone membrane | |
Biological Process | synaptic vesicle priming |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSynaptosomal-associated protein 25-A
- Short namesSNAP-25A
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ5TZ66
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Complexed with macromolecular elements of the nerve terminal.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000355574 | 1-204 | Synaptosomal-associated protein 25-A | |||
Sequence: MAEDSDMRNELADMQQRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKDAEKNLNDLGKFCGLCSCPCNKMKSGASKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTDDARENEMDENLEQVGGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG |
Proteomic databases
Expression
Tissue specificity
Expressed in several regions throughout the adult brain, including the mesencephalon.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: MAEDSDMRNELADMQQRADQLADES | ||||||
Domain | 19-81 | t-SNARE coiled-coil homology 1 | ||||
Sequence: DQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKDAEKNLNDL | ||||||
Domain | 138-200 | t-SNARE coiled-coil homology 2 | ||||
Sequence: DARENEMDENLEQVGGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKM |
Sequence similarities
Belongs to the SNAP-25 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Isoforms differ by the usage of two alternative homologous exons which code for positions 55 to 94 and differ only in 11 positions out of 40.
Q5TZ66-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length204
- Mass (Da)22,857
- Last updated2004-12-07 v1
- ChecksumB53CF5F3D1C69EA5
Q5TZ66-2
- Name2
- Differences from canonical
- 58-89: ERIEEGMDQINKDMKDAEKNLNDLGKFCGLCS → DRVEDGMNHINQDMKEAEKNLKDLGKCCGLFI
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_052974 | 58-89 | in isoform 2 | |||
Sequence: ERIEEGMDQINKDMKDAEKNLNDLGKFCGLCS → DRVEDGMNHINQDMKEAEKNLKDLGKCCGLFI | ||||||
Sequence conflict | 190 | in Ref. 2; AAH63942 | ||||
Sequence: I → F |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX465184 EMBL· GenBank· DDBJ | CAH69031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX470246 EMBL· GenBank· DDBJ | CAH69031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX465184 EMBL· GenBank· DDBJ | CAH69032.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX470246 EMBL· GenBank· DDBJ | CAH69032.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX470246 EMBL· GenBank· DDBJ | CAI21359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX465184 EMBL· GenBank· DDBJ | CAI21359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX470246 EMBL· GenBank· DDBJ | CAI21360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX465184 EMBL· GenBank· DDBJ | CAI21360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC063942 EMBL· GenBank· DDBJ | AAH63942.1 EMBL· GenBank· DDBJ | mRNA | ||
AF091593 EMBL· GenBank· DDBJ | AAC64289.1 EMBL· GenBank· DDBJ | mRNA |