Q5TX47 · STX1A_ANOGA

Function

function

Plays a critical role in several secretory processes.

Features

Showing features for site.

129020406080100120140160180200220240260280
TypeIDPosition(s)Description
Site240-241(Microbial infection) Cleavage; by P.bifermentans PMP1 light chain (LC)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendomembrane system
Cellular Componentplasma membrane
Cellular Componentpresynaptic active zone membrane
Cellular ComponentSNARE complex
Cellular Componentsynaptic vesicle
Cellular Componentsynaptic vesicle membrane
Molecular FunctionSNAP receptor activity
Molecular FunctionSNARE binding
Biological Processexocytosis
Biological Processintracellular protein transport
Biological Processsynaptic vesicle fusion to presynaptic active zone membrane
Biological Processvesicle docking

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Syntaxin-1A

Gene names

    • Name
      Syx1A
    • ORF names
      AgaP_AGAP007698

Organism names

  • Taxonomic identifier
  • Strain
    • PEST
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    Q5TX47

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-267Cytoplasmic
Transmembrane268-289Helical; Anchor for type IV membrane protein
Topological domain290Vesicular

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis238Very poorly cleaved in vitro by PMP1 LC.
Mutagenesis243Very poorly cleaved in vitro by PMP1 LC.
Mutagenesis247-248Very poorly cleaved in vitro by PMP1 LC.
Mutagenesis250-251Very poorly cleaved in vitro by PMP1 LC.
Mutagenesis257No longer cleaved in vitro by PMP1 LC.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004578821-290Syntaxin-1A

Post-translational modification

(Microbial infection) Targeted and hydrolyzed by the light chain (LC) of P.bifermentans PMP1. Cleavage probably inhibits neurotransmitter release.

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-21Disordered
Domain194-256t-SNARE coiled-coil homology

Sequence similarities

Belongs to the syntaxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    290
  • Mass (Da)
    33,515
  • Last updated
    2007-10-23 v2
  • MD5 Checksum
    BA32E47B8909F3DD92A4D5DD4D43ED24
MTKDRLAALQAAQSDDEDMPEDVAVPVEGSFMEDFFKEVEEIRMMIDKIQANVEEVKKKHSAILSAPQSDEKTKQELEDLMADIKKTANRVRGKLKGIEQNIEQEEQQSKSNADLRIRKTQHSALSRKFVEVMTEYNRTQTDYRERCKGRIQRQLEITGRATTNEELEEMLEQGNSAVFTQGIIMETQQAKQTLADIEARHADIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYHVEHAMDYVQTATQDTKKALKYQSKARRKKIWIAICVLIAIIILVVFLAIYLT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A7UR53A7UR53_ANOGA1269535287

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAAB01008807
EMBL· GenBank· DDBJ
EAL41719.2
EMBL· GenBank· DDBJ
Genomic DNA
AAAB01008807
EMBL· GenBank· DDBJ
EDO64509.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help