Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5alpha Promotes Cancer Invasion and Tumor Growth.
in the invadopodia-competent Src-3T3 model system mutations in any one of the first three SH3 domains had a dominant negative effect that largely eliminated the presence of invadopodia inhibited gelatin degradation activity and redistributed both Src cortactin and Tks5 to what are likely endosomal compartments
The present GWAS was the first to implicate SH3PXD2A in non-syndromic cleft formation in humans. In summary although performed in a relatively small sample the present GWAS generated novel insights into nsCL/P etiology.
TKS5 is expressed in human pancreatic adenocarcinoma lines. TKS5 localizes at mature and immature invadopodia in pancreatic cancer cells. Pancreatic cancer cells depend on TKS5 for invadopodia formation and function.
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