Q5TAG4 · NBPFC_HUMAN
- ProteinNeuroblastoma breakpoint family member 12
- GeneNBPF12
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1457 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Miscellaneous
Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNeuroblastoma breakpoint family member 12
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ5TAG4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,134 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000288047 | 1-1457 | Neuroblastoma breakpoint family member 12 | |||
Sequence: MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNLKERCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSTVVVDRKSSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKYEECKDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSSPREMQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDKVNSSLVVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLLKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLAEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLSRELLAEKEPEVLQDSLDRWYSTPSVYLGLTDPCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLNSVLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHITFALDMDNSFFTLTVTSLHLVFQMGVIFPQ |
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed with highest levels in brain, ovary, mammary gland, skin and adipose tissue. Also expressed in testis. Detected in a number of tumors including osteosarcoma, mammary carcinoma and hepatocellular carcinoma.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 75-119 | |||||
Sequence: RQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA | ||||||
Region | 162-200 | Disordered | ||||
Sequence: LSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVP | ||||||
Compositional bias | 165-179 | Acidic residues | ||||
Sequence: ENDEDEDEDVQVEED | ||||||
Domain | 165-259 | Olduvai 1 | ||||
Sequence: ENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSTVVVDRKSSHDECQDALNILP | ||||||
Compositional bias | 180-200 | Basic and acidic residues | ||||
Sequence: EKVLESSAPREVQKAEESKVP | ||||||
Coiled coil | 339-390 | |||||
Sequence: KSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA | ||||||
Region | 432-472 | Disordered | ||||
Sequence: KLSPENDEDEDEDVQVEEDEKVLESSSPREMQKAEESKVPE | ||||||
Compositional bias | 436-450 | Acidic residues | ||||
Sequence: ENDEDEDEDVQVEED | ||||||
Domain | 436-530 | Olduvai 2 | ||||
Sequence: ENDEDEDEDVQVEEDEKVLESSSPREMQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDKVNSSLVVDRESSHDECQDALNILP | ||||||
Compositional bias | 451-472 | Basic and acidic residues | ||||
Sequence: EKVLESSSPREMQKAEESKVPE | ||||||
Coiled coil | 610-661 | |||||
Sequence: KSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA | ||||||
Domain | 707-799 | Olduvai 3 | ||||
Sequence: ENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIP | ||||||
Region | 721-746 | Disordered | ||||
Sequence: AEKVQKSSSPREMQKAEEKEVPEDSL | ||||||
Region | 791-838 | Disordered | ||||
Sequence: WEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYST | ||||||
Domain | 800-871 | Olduvai 4 | ||||
Sequence: ENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG | ||||||
Compositional bias | 810-824 | Basic and acidic residues | ||||
Sequence: EKGPVSPRNLQESEE | ||||||
Domain | 872-963 | Olduvai 5 | ||||
Sequence: RHRWDQVKKEDQEATGPRLSRELLAEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCP | ||||||
Domain | 966-1021 | Olduvai 6 | ||||
Sequence: SRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD | ||||||
Domain | 1022-1114 | Olduvai 7 | ||||
Sequence: RIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKK | ||||||
Region | 1100-1139 | Disordered | ||||
Sequence: KKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLSRELL | ||||||
Compositional bias | 1103-1118 | Basic residues | ||||
Sequence: KGKKRRGRRSKKKRRR | ||||||
Domain | 1115-1207 | Olduvai 8 | ||||
Sequence: KRRRGRKEGEEDQNPPCPRLSRELLAEKEPEVLQDSLDRWYSTPSVYLGLTDPCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCP | ||||||
Compositional bias | 1119-1139 | Basic and acidic residues | ||||
Sequence: GRKEGEEDQNPPCPRLSRELL | ||||||
Domain | 1210-1265 | Olduvai 9 | ||||
Sequence: SRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD | ||||||
Domain | 1266-1358 | Olduvai 10 | ||||
Sequence: RIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKK | ||||||
Region | 1344-1378 | Disordered | ||||
Sequence: KKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRL | ||||||
Compositional bias | 1347-1362 | Basic residues | ||||
Sequence: KGKKRRGRRSKKKRRR | ||||||
Domain | 1359-1457 | Olduvai 11 | ||||
Sequence: KRRRGRKEGEEDQNPPCPRLNSVLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHITFALDMDNSFFTLTVTSLHLVFQMGVIFPQ |
Sequence similarities
Belongs to the NBPF family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,457
- Mass (Da)167,689
- Last updated2018-03-28 v3
- Checksum0AE1FB4CBD2C1094
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V8TNX8 | A0A8V8TNX8_HUMAN | NBPF12 | 942 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 165-179 | Acidic residues | ||||
Sequence: ENDEDEDEDVQVEED | ||||||
Compositional bias | 180-200 | Basic and acidic residues | ||||
Sequence: EKVLESSAPREVQKAEESKVP | ||||||
Compositional bias | 436-450 | Acidic residues | ||||
Sequence: ENDEDEDEDVQVEED | ||||||
Compositional bias | 451-472 | Basic and acidic residues | ||||
Sequence: EKVLESSSPREMQKAEESKVPE | ||||||
Compositional bias | 810-824 | Basic and acidic residues | ||||
Sequence: EKGPVSPRNLQESEE | ||||||
Compositional bias | 1103-1118 | Basic residues | ||||
Sequence: KGKKRRGRRSKKKRRR | ||||||
Compositional bias | 1119-1139 | Basic and acidic residues | ||||
Sequence: GRKEGEEDQNPPCPRLSRELL | ||||||
Compositional bias | 1347-1362 | Basic residues | ||||
Sequence: KGKKRRGRRSKKKRRR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL139152 EMBL· GenBank· DDBJ | CAI22485.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
AC244394 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AF131738 EMBL· GenBank· DDBJ | AAD20027.1 EMBL· GenBank· DDBJ | mRNA |