Q5T6X5 · GPC6A_HUMAN
- ProteinG-protein coupled receptor family C group 6 member A
- GeneGPRC6A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids926 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628).
Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628).
The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+ (By similarity).
Seems to act through a G(q)/G11 and G(i)-coupled pathway (By similarity).
Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity).
Mediates the non-genomic effects of androgens in multiple tissue (By similarity).
May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:20947496).
Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628).
The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+ (By similarity).
Seems to act through a G(q)/G11 and G(i)-coupled pathway (By similarity).
Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity).
Mediates the non-genomic effects of androgens in multiple tissue (By similarity).
May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:20947496).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | regulation of testosterone biosynthetic process | |
Biological Process | response to amino acid |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameG-protein coupled receptor family C group 6 member A
- Short nameshGPRC6A
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ5T6X5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 19-594 | Extracellular | ||||
Sequence: QPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLA | ||||||
Transmembrane | 595-615 | Helical; Name=1 | ||||
Sequence: ILLLILSLLGIIFVLVVGIIF | ||||||
Topological domain | 616-631 | Cytoplasmic | ||||
Sequence: TRNLNTPVVKSSGGLR | ||||||
Transmembrane | 632-652 | Helical; Name=2 | ||||
Sequence: VCYVILLCHFLNFASTSFFIG | ||||||
Topological domain | 653-669 | Extracellular | ||||
Sequence: EPQDFTCKTRQTMFGVS | ||||||
Transmembrane | 670-690 | Helical; Name=3 | ||||
Sequence: FTLCISCILTKSLKILLAFSF | ||||||
Topological domain | 691-704 | Cytoplasmic | ||||
Sequence: DPKLQKFLKCLYRP | ||||||
Transmembrane | 705-725 | Helical; Name=4 | ||||
Sequence: ILIIFTCTGIQVVICTLWLIF | ||||||
Topological domain | 726-748 | Extracellular | ||||
Sequence: AAPTVEVNVSLPRVIILECEEGS | ||||||
Transmembrane | 749-769 | Helical; Name=5 | ||||
Sequence: ILAFGTMLGYIAILAFICFIF | ||||||
Topological domain | 770-782 | Cytoplasmic | ||||
Sequence: AFKGKYENYNEAK | ||||||
Transmembrane | 783-803 | Helical; Name=6 | ||||
Sequence: FITFGMLIYFIAWITFIPIYA | ||||||
Topological domain | 804-810 | Extracellular | ||||
Sequence: TTFGKYV | ||||||
Transmembrane | 811-831 | Helical; Name=7 | ||||
Sequence: PAVEIIVILISNYGILYCTFI | ||||||
Topological domain | 832-926 | Cytoplasmic | ||||
Sequence: PKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_023966 | 91 | in dbSNP:rs2274911 | |||
Sequence: P → S | ||||||
Natural variant | VAR_049283 | 144 | in dbSNP:rs28360548 | |||
Sequence: I → R | ||||||
Mutagenesis | 149 | Loss of function. | ||||
Sequence: S → A | ||||||
Mutagenesis | 172 | Loss of function. | ||||
Sequence: T → A | ||||||
Natural variant | VAR_061203 | 599 | in dbSNP:rs35937022 | |||
Sequence: I → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,175 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MAFLIILITCFVIILATS | ||||||
Chain | PRO_0000043196 | 19-926 | G-protein coupled receptor family C group 6 member A | |||
Sequence: QPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI | ||||||
Glycosylation | 121 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 131 | Interchain | ||||
Sequence: C | ||||||
Glycosylation | 259 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 332 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 378 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 452 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 555 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 567 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 590 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 733 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.
Gene expression databases
Organism-specific databases
Structure
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
Q5T6X5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- NoteMajor isoform.
- Length926
- Mass (Da)104,753
- Last updated2004-12-21 v1
- Checksum2019C884FF092EEF
Q5T6X5-2
- Name2
- Differences from canonical
- 271-445: Missing
Q5T6X5-3
- Name3
- Differences from canonical
- 446-516: Missing
Sequence caution
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY435125 EMBL· GenBank· DDBJ | AAS13465.1 EMBL· GenBank· DDBJ | mRNA | ||
AY435126 EMBL· GenBank· DDBJ | AAS13466.1 EMBL· GenBank· DDBJ | mRNA | ||
AY435127 EMBL· GenBank· DDBJ | AAS13467.1 EMBL· GenBank· DDBJ | mRNA | ||
AF502962 EMBL· GenBank· DDBJ | AAM22230.1 EMBL· GenBank· DDBJ | mRNA | ||
AL354716 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AB065680 EMBL· GenBank· DDBJ | BAC05904.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AB083615 EMBL· GenBank· DDBJ | BAB89328.1 EMBL· GenBank· DDBJ | Genomic DNA |