Q5T5C0 · STXB5_HUMAN
- ProteinSyntaxin-binding protein 5
- GeneSTXBP5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1151 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | acetylcholine-gated channel complex | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | extrinsic component of neuronal dense core vesicle membrane | |
Cellular Component | hippocampal mossy fiber to CA3 synapse | |
Cellular Component | plasma membrane | |
Cellular Component | SNARE complex | |
Cellular Component | synaptic vesicle | |
Molecular Function | GTPase activator activity | |
Molecular Function | myosin II binding | |
Molecular Function | syntaxin binding | |
Molecular Function | syntaxin-1 binding | |
Biological Process | exocytosis | |
Biological Process | Golgi to plasma membrane transport | |
Biological Process | positive regulation of exocytosis | |
Biological Process | protein transport | |
Biological Process | regulation of exocytosis | |
Biological Process | regulation of synaptic vesicle exocytosis | |
Biological Process | regulation of synaptic vesicle priming |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSyntaxin-binding protein 5
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ5T5C0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Cytoplasmic vesicle membrane ; Peripheral membrane protein
Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity).
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_035235 | 436 | in dbSNP:rs1039084 | |||
Sequence: N → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,010 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000051244 | 1-1151 | UniProt | Syntaxin-binding protein 5 | |||
Sequence: MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSPHNSDDEQKMNNFIEKVKTKSRKFSKMVANDIAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF | |||||||
Modified residue (large scale data) | 193 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 688 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 692 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 692 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 700 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 719 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 723 | UniProt | Phosphoserine; by PKA | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 723 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 759 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 759 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 762 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 778 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 780 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 781 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 782 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 782 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 784 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 784 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 785 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 785 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 790 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 900 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 900 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 902 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 902 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 906 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1039 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1039 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 1058 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1058 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1131 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1131 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 14-34 | Disordered | ||||
Sequence: TAGSSSASQQQQQQHPPGNRE | ||||||
Repeat | 61-94 | WD 1 | ||||
Sequence: SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQ | ||||||
Repeat | 101-140 | WD 2 | ||||
Sequence: VIQLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKF | ||||||
Repeat | 145-181 | WD 3 | ||||
Sequence: VTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVI | ||||||
Repeat | 200-234 | WD 4 | ||||
Sequence: HISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRY | ||||||
Repeat | 240-272 | WD 5 | ||||
Sequence: IHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKP | ||||||
Repeat | 294-336 | WD 6 | ||||
Sequence: PILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTA | ||||||
Repeat | 344-378 | WD 7 | ||||
Sequence: IVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDL | ||||||
Repeat | 400-477 | WD 8 | ||||
Sequence: TCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLK | ||||||
Repeat | 505-619 | WD 9 | ||||
Sequence: QIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVI | ||||||
Region | 555-595 | Disordered | ||||
Sequence: ETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRD | ||||||
Compositional bias | 559-581 | Pro residues | ||||
Sequence: GEQPPPLPTPVGGSNPQPIPPQS | ||||||
Repeat | 633-695 | WD 10 | ||||
Sequence: TSLAVNSSYGLVVFGNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAG | ||||||
Region | 674-729 | Disordered | ||||
Sequence: SNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSPHNSDDEQKM | ||||||
Compositional bias | 710-726 | Polar residues | ||||
Sequence: CKSPTSGSSSPHNSDDE | ||||||
Repeat | 794-851 | WD 11 | ||||
Sequence: ISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTI | ||||||
Repeat | 860-934 | WD 12 | ||||
Sequence: RMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCA | ||||||
Compositional bias | 881-898 | Basic and acidic residues | ||||
Sequence: HNVPEEKDEKEKLKKRRP | ||||||
Region | 881-906 | Disordered | ||||
Sequence: HNVPEEKDEKEKLKKRRPVSVSPSSS | ||||||
Repeat | 939-983 | WD 13 | ||||
Sequence: ITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVY | ||||||
Repeat | 997-1020 | WD 14 | ||||
Sequence: CFTNNGQALYLVSPTEIQRLTYSQ | ||||||
Domain | 1086-1146 | v-SNARE coiled-coil homology | ||||
Sequence: GIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKDK |
Sequence similarities
Belongs to the WD repeat L(2)GL family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q5T5C0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,151
- Mass (Da)127,573
- Last updated2004-12-21 v1
- Checksum247083A17DEA4811
Q5T5C0-2
- Name2
- Differences from canonical
- 716-751: Missing
Q5T5C0-3
- Name3
- Differences from canonical
- 716-768: Missing
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F6VFW0 | F6VFW0_HUMAN | STXBP5 | 344 | ||
H0Y332 | H0Y332_HUMAN | STXBP5 | 1135 | ||
A0A9L9PXY2 | A0A9L9PXY2_HUMAN | STXBP5 | 770 | ||
A0A9L9PY07 | A0A9L9PY07_HUMAN | STXBP5 | 970 |
Sequence caution
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 559-581 | Pro residues | ||||
Sequence: GEQPPPLPTPVGGSNPQPIPPQS | ||||||
Compositional bias | 710-726 | Polar residues | ||||
Sequence: CKSPTSGSSSPHNSDDE | ||||||
Alternative sequence | VSP_016205 | 716-751 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_016204 | 716-768 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 881-898 | Basic and acidic residues | ||||
Sequence: HNVPEEKDEKEKLKKRRP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL356415 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL355365 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL590709 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC113382 EMBL· GenBank· DDBJ | AAI13383.1 EMBL· GenBank· DDBJ | mRNA | ||
AK055484 EMBL· GenBank· DDBJ | BAB70930.1 EMBL· GenBank· DDBJ | mRNA | ||
AK090549 EMBL· GenBank· DDBJ | BAC03475.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |