Q5SZV5 · K0319_MOUSE

  • Protein
    Dyslexia-associated protein KIAA0319 homolog
  • Gene
    Kiaa0319
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentearly endosome
Cellular Componentearly endosome membrane
Cellular Componentplasma membrane
Biological Processmulticellular organismal response to stress
Biological Processnegative regulation of axon extension
Biological Processnegative regulation of axon extension involved in regeneration
Biological Processnegative regulation of dendrite development
Biological Processneuron migration
Biological Processpositive regulation of SMAD protein signal transduction
Biological Processresponse to auditory stimulus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dyslexia-associated protein KIAA0319 homolog

Gene names

    • Name
      Kiaa0319

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5SZV5
  • Secondary accessions
    • Q14BF3
    • Q80U39

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Early endosome membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain23-964Extracellular
Transmembrane965-985Helical
Topological domain986-1081Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_000004294723-1081Dyslexia-associated protein KIAA0319 homolog
Glycosylation196N-linked (GlcNAc...) asparagine
Glycosylation228N-linked (GlcNAc...) asparagine
Glycosylation272N-linked (GlcNAc...) asparagine
Glycosylation302N-linked (GlcNAc...) asparagine
Glycosylation430N-linked (GlcNAc...) asparagine
Glycosylation507N-linked (GlcNAc...) asparagine
Glycosylation522N-linked (GlcNAc...) asparagine
Glycosylation545N-linked (GlcNAc...) asparagine
Glycosylation560N-linked (GlcNAc...) asparagine
Glycosylation742N-linked (GlcNAc...) asparagine
Modified residue1009Phosphoserine

Post-translational modification

N-glycosylated.
O-glycosylated.
Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed in the frontal neocortex, glanglionic eminence, mesencephalon and cerebellum at 13.5 dpc. More prominently expressed in the developing cerebral neocortex and mesencephalon at 15.5 dpc and in the cortical plate and in the remnant of the ventricular zone at 18.5 dpc.

Gene expression databases

Interaction

Subunit

Homodimer. Interacts with AP2M1; required for clathrin-mediated endocytosis (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, motif.

TypeIDPosition(s)Description
Domain23-99MANSC
Region168-331Disordered
Compositional bias191-210Polar residues
Compositional bias218-250Polar residues
Compositional bias264-327Polar residues
Domain345-436PKD 1
Domain444-533PKD 2
Domain539-629PKD 3
Domain630-723PKD 4
Domain729-820PKD 5
Motif1004-1007Endocytosis signal

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,081
  • Mass (Da)
    117,988
  • Last updated
    2004-12-21 v1
  • Checksum
    C142C9746D9AF4DA
MVSPPGVLSSLLLLAAMAGGSSQQCSEGRTYSDAIISPNPETIRIMRVSQTFSVGDCTAACCDLLTCDLAWWFEGSCYLVKCMRSENCEPRTTGPIRSYLTFVRRPVQRPGQLLDYGDMMLSRGSPSGAWGDSLEDLRKDLPFLGKDGGPEETTEYSDEYKDLERGLLQPSNQQDPRGSAEYPDWSLLPSNEGGFNATATGDNSAASMEKLQDPTPHPLDQEQLQALNESTWSPTPGHSSISSVWPSSASPLPTEEGLEGEETLQLQEQPSNSSGKEVPMPSHNPSPASLESSPATTEKNSNFTVTPRSRKHSTPTFPTSTVLTGLTPPPWPLSPTASRTVKALAVSAGDNLVLTLPDREAELKASVEPAPPADTTYSYEWSLMSHPVDFQGKIKQENKPTLHLSQLSVGLYAFRVAVSSENAFGEGYVNVTVMPAARVNQPPVAVVSPQTQELSVPLTSALIDGSQSTDDTEIVSYHWEEVDGPFLGEEFPADTPILRLSNLVPGNYTFRLTITDSDGATNSTTASLVIRDAVDYPPVANAGPNQTITLPQNTIILNGNQSSDDHQIVLYEWFAGPGGESKEMVMQGAQTPYLHLSELQEGEYTFQLMVTDSSGQQSTALVAVTVQAENNQAPVAVAGPDKELVFPVQSATLDGSRSSDDHGIVCYHWEHIRGPSAVEMENVDKAIATVTGLQVGIYHFRLTVRDQQGLSSTSTLTVAVKKENNSPPRAQAGGRHVLILPNNSITLDGSRSTDDRGIVSYLWIRDGQSPAAGDVIGGSDHRAALQLTNLVEGVYTFHLLVTDSQGASDSDAATVEVLPDPKKDGLVELILQVGVEQLTEQQKETLVRQLAVLLNVLDSDVKVLKIQAHTDVSTVIVFYVQSGSPFKVLRAAAVARNLHKRLSKEKEAFLLFKVLRVDTAGCLLKCSGHGHCDPITKRCICSQLWMENLIQRYMWDGESNCEWSVFYVAALALTLTLLTGAVSWLCICCCRRRKRTKIRKKTKYTILDSMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFESDQDTLFSRERMERGVLKGSLNGCARNGVSFGYYSKDR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F2Z497F2Z497_MOUSED130043K22Rik782

Sequence caution

The sequence BAC65528.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias191-210Polar residues
Compositional bias218-250Polar residues
Compositional bias264-327Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK122246
EMBL· GenBank· DDBJ
BAC65528.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL589699
EMBL· GenBank· DDBJ
CAI26085.1
EMBL· GenBank· DDBJ
Genomic DNA
BC115723
EMBL· GenBank· DDBJ
AAI15724.1
EMBL· GenBank· DDBJ
mRNA
BC115940
EMBL· GenBank· DDBJ
AAI15941.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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