Q5SX78 · Q5SX78_MOUSE

  • Protein
    Granulocyte-macrophage colony-stimulating factor
  • Gene
    Csf2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentgranulocyte macrophage colony-stimulating factor receptor complex
Cellular Componentintracellular membrane-bounded organelle
Molecular Functioncytokine activity
Molecular Functiongranulocyte macrophage colony-stimulating factor receptor binding
Molecular Functiongrowth factor activity
Biological Processcell surface receptor signaling pathway via JAK-STAT
Biological Processcellular response to granulocyte macrophage colony-stimulating factor stimulus
Biological Processgranulocyte-macrophage colony-stimulating factor signaling pathway
Biological Processimmune response
Biological Processmacrophage differentiation
Biological Processmyeloid dendritic cell differentiation
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Processpositive regulation of interleukin-23 production
Biological Processpositive regulation of leukocyte proliferation
Biological Processpositive regulation of macrophage derived foam cell differentiation
Biological Processpositive regulation of podosome assembly
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein

Names & Taxonomy

Protein names

  • Recommended name
    Granulocyte-macrophage colony-stimulating factor
  • Alternative names
    • Colony-stimulating factor

Gene names

    • Name
      Csf2

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C57BL/6J
    • C57BL/6
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5SX78

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_501084458318-141Granulocyte-macrophage colony-stimulating factor

Expression

Gene expression databases

Interaction

Subunit

Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.

Structure

Family & Domains

Sequence similarities

Belongs to the GM-CSF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    141
  • Mass (Da)
    16,091
  • Last updated
    2005-05-10 v1
  • Checksum
    209C7CBB4FF77349
MWLQNLLFLGIVVYSLSAPTRSPITVTRPWKHVEAIKEALNLLDDMPVTLNEEVEVVSNEFSFKKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFECKKPGQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU366957
EMBL· GenBank· DDBJ
ABY66391.1
EMBL· GenBank· DDBJ
mRNA
AK053196
EMBL· GenBank· DDBJ
BAE20692.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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