Q5SQX6 · CYFP2_MOUSE
- ProteinCytoplasmic FMR1-interacting protein 2
- GeneCyfip2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1253 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity).
Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity).
Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).
Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity).
Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | neuron projection | |
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | SCAR complex | |
Cellular Component | synapse | |
Molecular Function | small GTPase binding | |
Biological Process | apoptotic process | |
Biological Process | axon guidance | |
Biological Process | cell morphogenesis | |
Biological Process | cell projection assembly | |
Biological Process | cell-cell adhesion | |
Biological Process | dendrite extension | |
Biological Process | neuron projection development | |
Biological Process | positive regulation of neurotrophin TRK receptor signaling pathway | |
Biological Process | positive regulation of proteolysis | |
Biological Process | regulation of actin filament polymerization |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytoplasmic FMR1-interacting protein 2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5SQX6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Highly expressed in the perinuclear region and enriched in synaptosomes (PubMed:11438699).
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 320 | in RNA edited version | ||||
Sequence: K → E |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 63 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000279710 | 1-1253 | Cytoplasmic FMR1-interacting protein 2 | |||
Sequence: MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHDYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC | ||||||
Modified residue | 1037 | N6-acetyllysine | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in hippocampus (at protein level).
Gene expression databases
Interaction
Subunit
Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Interacts with FMR1, FXR1 and FXR2 (PubMed:11438699).
Interacts with FMR1; the interaction occurs in a RNA-dependent manner (By similarity).
Interacts with RAC1 (activated form) which causes the complex to dissociate, releasing activated WASF1 (By similarity).
The complex can also be activated by NCK1 (By similarity).
Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex (PubMed:24153177).
Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (PubMed:27605705).
Interacts with FMR1; the interaction occurs in a RNA-dependent manner (By similarity).
Interacts with RAC1 (activated form) which causes the complex to dissociate, releasing activated WASF1 (By similarity).
The complex can also be activated by NCK1 (By similarity).
Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex (PubMed:24153177).
Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (PubMed:27605705).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q5SQX6 | Shank3 Q4ACU6 | 3 | EBI-773783, EBI-771450 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length1,253
- Mass (Da)145,659
- Last updated2005-02-01 v2
- Checksum321011BF830F424E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 76 | in Ref. 3; BAC26942 | ||||
Sequence: G → V | ||||||
Sequence conflict | 229 | in Ref. 3; BAE27779 | ||||
Sequence: E → G | ||||||
Sequence conflict | 242 | in Ref. 3; BAE27779 | ||||
Sequence: V → A | ||||||
Sequence conflict | 678 | in Ref. 3; BAC26942 | ||||
Sequence: L → P | ||||||
Sequence conflict | 1080 | in Ref. 3; BAC26942 | ||||
Sequence: L → P |
RNA Editing
Edited at position 320
Partially edited. Editing appears to be brain-specific
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF334144 EMBL· GenBank· DDBJ | AAK81821.1 EMBL· GenBank· DDBJ | mRNA | ||
AB093288 EMBL· GenBank· DDBJ | BAC41472.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK030397 EMBL· GenBank· DDBJ | BAC26942.1 EMBL· GenBank· DDBJ | mRNA | ||
AK147224 EMBL· GenBank· DDBJ | BAE27779.1 EMBL· GenBank· DDBJ | mRNA | ||
AK147586 EMBL· GenBank· DDBJ | BAE28010.1 EMBL· GenBank· DDBJ | mRNA | ||
AK147632 EMBL· GenBank· DDBJ | BAE28036.1 EMBL· GenBank· DDBJ | mRNA | ||
AL662806 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL713958 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AF162472 EMBL· GenBank· DDBJ | AAD45803.1 EMBL· GenBank· DDBJ | mRNA |