Q5SPD5 · Q5SPD5_DANRE

Function

function

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionGDP-L-fucose synthase activity
Biological Process'de novo' GDP-L-fucose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GDP-L-fucose synthase
  • EC number
  • Alternative names
    • GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase

Gene names

    • Name
      gfus.1
    • Synonyms
      gfus
      , si:dkey-235d18none
      , tsta3
      , zgc:101805

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q5SPD5
  • Secondary accessions
    • B2GNW2

Proteomes

Organism-specific databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-242NAD-dependent epimerase/dehydratase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    318
  • Mass (Da)
    36,073
  • Last updated
    2004-12-21 v1
  • Checksum
    7922D0B7DA920FB9
MDGPMRVLVTGGSGLVGRAIERVVKEGEGREGEEWIFLSSKDANLLSPEETKAVFEKHRPTHVIHLAAMVGGLFRNMRQNLDFWRSNVFINDNVLQAAHDSGVVKVVSCLSTCIFPDKTTYPIDETMIHNGPPHESNFGYAYAKRMIDVQNRAFFQQFNRRYTAVIPTNVFGCHDNFNIEDGHVLPGLIHKTYIAKKEGKPLVVWGSGRPLRQFIYSLDLARLFVWVLREYDEVEPIILSVGEEDELSIKDAADAVVEALEFTGDVIYDTSKADGQFKKTASNAKLRKYLPDFKFTPFREAIKETCDWFVANYDTARK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL929003
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC086741
EMBL· GenBank· DDBJ
AAH86741.1
EMBL· GenBank· DDBJ
mRNA
BC164117
EMBL· GenBank· DDBJ
AAI64117.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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