Comparative analysis of ribosomal protein L5 sequences from bacteria of the genus Thermus.Jahn O., Hartmann R.K., Boeckh T., Erdmann V.A.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochimie 73:669-678 (1991)Cited in3
Identification, purification and partial sequence of four Thermus thermophilus 5S rRNA binding proteins.Kim J.-S., Boysen R.I., Schroeder W., Erdmann V.A., Gessner R.V.Cited forPROTEIN SEQUENCE OF 2-44, ISOLATION OF 5S RRNA-ASSOCIATED COMPLEXESCategoriesSequences, InteractionSourceUniProtKB reviewed (Swiss-Prot)Endocyt. Cell Res. 11:177-194 (1996)Cited in3
The isolation and complete amino acid sequence of the ribosomal protein L36 from Thermus thermophilus and its zinc-binding motif.Boysen R.I., Lorenz S., Kim J.S., Schroeder W.F.K.J., Erdmann V.A.Cited forPROTEIN SEQUENCE OF 2-41CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)Endocyt. Cell Res. 11:41-58 (1995)Cited in9
Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus.Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.View abstractCited forPROTEIN SEQUENCE OF 2-28StrainATCC 27634 / DSM 579 / HB8CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiol. Chem. 381:1079-1087 (2000)Cited in32
The path of messenger RNA through the ribosome.Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.View abstractCited forX-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOMECategoryStructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 106:233-241 (2001)Cited in41
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.Aleksandrova E.V., Ma C.X., Klepacki D., Alizadeh F., Vazquez-Laslop N., Liang J.H., Polikanov Y.S., Mankin A.S.View abstractCategoryStructureSourcePDB: 8VTU, PDB: 8VTV, PDB: 8VTW, PDB: 8VTX, PDB: 8VTYPubMedEurope PMCNat Chem Biol 0:0-0 (2024)Mapped to50
Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity.Batool Z., Pavlova J.A., Paranjpe M.N., Tereshchenkov A.G., Lukianov D.A., Osterman I.A., Bogdanov A.A., Sumbatyan N.V., Polikanov Y.S.View abstractCategoryStructureSourcePDB: 9B00PubMedEurope PMCStructure 32:1429-1442.e6 (2024)Mapped to49
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.Wu K.J.Y., Tresco B.I.C., Ramkissoon A., Aleksandrova E.V., Syroegin E.A., See D.N.Y., Liow P., Dittemore G.A., Yu M.[...], Myers A.G.View abstractCategoryStructureSourcePDB: 8UD6, PDB: 8UD7, PDB: 8UD8PubMedEurope PMCScience 383:721-726 (2024)Mapped to49
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.Aleksandrova E.V., Wu K.J.Y., Tresco B.I.C., Syroegin E.A., Killeavy E.E., Balasanyants S.M., Svetlov M.S., Gregory S.T., Atkinson G.C.[...], Polikanov Y.S.View abstractCategoryStructureSourcePDB: 8G29, PDB: 8G2A, PDB: 8G2B, PDB: 8G2C, PDB: 8G2DPubMedEurope PMCNat Chem Biol 20:867-876 (2024)Mapped to49
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in <i>Mycobacterium</i> abscessus.Phelps G.A., Cheramie M.N., Fernando D.M., Selchow P., Meyer C.J., Waidyarachchi S.L., Dharuman S., Liu J., Meuli M.[...], Lee R.E.View abstractCategoryStructureSourcePDB: 8UVR, PDB: 8UVSPubMedEurope PMCProc Natl Acad Sci U S A 121:e2314101120-e2314101120 (2024)Mapped to49
Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.Chen C.W., Leimer N., Syroegin E.A., Dunand C., Bulman Z.P., Lewis K., Polikanov Y.S., Svetlov M.S.View abstractCategoryStructureSourcePDB: 8FC1, PDB: 8FC2, PDB: 8FC3, PDB: 8FC4, PDB: 8FC5, PDB: 8FC6PubMedEurope PMCNat Commun 14:4196-4196 (2023)Mapped to50
Practical Synthesis of <i>N</i>-Formylmethionylated Peptidyl-tRNA Mimics.Thaler J., Syroegin E.A., Breuker K., Polikanov Y.S., Micura R.View abstractCategoryStructureSourcePDB: 8T8B, PDB: 8T8CPubMedEurope PMCACS Chem Biol 18:2233-2239 (2023)Mapped to50
Structural basis for reduced ribosomal A-site fidelity in response to P- site codon-anticodon mismatches.Nguyen H.A., Hoffer E.D., Fagan C.E., Maehigashi T., Dunham C.M.View abstractCategoryStructureSourcePDB: 8FOM, PDB: 8FONPubMedEurope PMCJ Biol Chem 299:104608-104608 (2023)Mapped to49
Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes.Syroegin E.A., Aleksandrova E.V., Polikanov Y.S.View abstractCategoryStructureSourcePDB: 8CVJ, PDB: 8CVK, PDB: 8CVLPubMedEurope PMCNat Chem 15:143-153 (2023)Mapped to49
Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine.Syroegin E.A., Aleksandrova E.V., Polikanov Y.S.View abstractCategoryStructureSourcePDB: 7U2H, PDB: 7U2I, PDB: 7U2JPubMedEurope PMCNucleic Acids Res 50:7669-7679 (2022)Mapped to49
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.Syroegin E.A., Flemmich L., Klepacki D., Vazquez-Laslop N., Micura R., Polikanov Y.S.View abstractCategoryStructureSourcePDB: 7RQA, PDB: 7RQB, PDB: 7RQC, PDB: 7RQD, PDB: 7RQEPubMedEurope PMCNat Struct Mol Biol 29:152-161 (2022)Mapped to50
A synthetic antibiotic class overcoming bacterial multidrug resistance.Mitcheltree M.J., Pisipati A., Syroegin E.A., Silvestre K.J., Klepacki D., Mason J.D., Terwilliger D.W., Testolin G., Pote A.R.[...], Myers A.G.View abstractCategoryStructureSourcePDB: 7RQ8, PDB: 7RQ9PubMedEurope PMCNature 599:507-512 (2021)Mapped to49
Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome.Chen C.W., Pavlova J.A., Lukianov D.A., Tereshchenkov A.G., Makarov G.I., Khairullina Z.Z., Tashlitsky V.N., Paleskava A., Konevega A.L.[...], Polikanov Y.S.View abstractCategoryStructureSourcePDB: 7MD7PubMedEurope PMCAntibiotics (Basel) 10:390-390 (2021)Mapped to50
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.Svetlov M.S., Syroegin E.A., Aleksandrova E.V., Atkinson G.C., Gregory S.T., Mankin A.S., Polikanov Y.S.View abstractCategoryStructureSourcePDB: 6XHV, PDB: 6XHW, PDB: 6XHX, PDB: 6XHYPubMedEurope PMCNat Chem Biol 17:412-420 (2021)Mapped to50
Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing.Hoffer E.D., Hong S., Sunita S., Maehigashi T., Gonzalez R.L., Whitford P.C., Dunham C.M.View abstractCategoryStructureSourcePDB: 6NSH, PDB: 6NTA, PDB: 6NUO, PDB: 6NWY, PDB: 6O3M, PDB: 6OSIPubMedEurope PMCElife 9:e51898-e51898 (2020)Mapped to49
Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.Batool Z., Lomakin I.B., Polikanov Y.S., Bunick C.G.View abstractCategoryStructureSourcePDB: 6XQD, PDB: 6XQEPubMedEurope PMCProc Natl Acad Sci U S A 117:20530-20537 (2020)Mapped to49
Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens.Mardirossian M., Sola R., Beckert B., Valencic E., Collis D.W.P., Borisek J., Armas F., Di Stasi A., Buchmann J.[...], Scocchi M.View abstractCategoryStructureSourcePDB: 7JQL, PDB: 7JQMPubMedEurope PMCJ Med Chem 63:9590-9602 (2020)Mapped to49
Disruption of evolutionarily correlated tRNA elements impairs accurate decoding.Nguyen H.A., Sunita S., Dunham C.M.View abstractCategoryStructureSourcePDB: 6OF6, PDB: 6OJ2, PDB: 6OPE, PDB: 6ORDPubMedEurope PMCProc Natl Acad Sci U S A 117:16333-16338 (2020)Mapped to49
Pseudouridinylation of mRNA coding sequences alters translation.Eyler D.E., Franco M.K., Batool Z., Wu M.Z., Dubuke M.L., Dobosz-Bartoszek M., Jones J.D., Polikanov Y.S., Roy B., Koutmou K.S.View abstractCategoryStructureSourcePDB: 6UO1PubMedEurope PMCProc Natl Acad Sci U S A 116:23068-23074 (2019)Mapped to49
Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.Rozov A., Khusainov I., El Omari K., Duman R., Mykhaylyk V., Yusupov M., Westhof E., Wagner A., Yusupova G.View abstractCategoryStructureSourcePDB: 6QNQ, PDB: 6QNRPubMedEurope PMCNat Commun 10:2519-2519 (2019)Mapped to50