Q5SGE0 · LPPRC_RAT
- ProteinLeucine-rich PPR motif-containing protein, mitochondrial
- GeneLrpprc
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1392 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (By similarity).
Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (By similarity).
May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).
Required for maintaining mitochondrial potential (By similarity).
Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (By similarity).
Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (By similarity).
May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).
Required for maintaining mitochondrial potential (By similarity).
Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | condensed nuclear chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | microtubule | |
Cellular Component | mitochondrial nucleoid | |
Cellular Component | mitochondrion | |
Cellular Component | nuclear inner membrane | |
Cellular Component | nuclear outer membrane | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | ribonucleoprotein complex | |
Molecular Function | beta-tubulin binding | |
Molecular Function | mRNA 3'-UTR binding | |
Molecular Function | RNA binding | |
Molecular Function | single-stranded DNA binding | |
Molecular Function | ubiquitin protein ligase binding | |
Biological Process | autophagy | |
Biological Process | mitochondrial RNA catabolic process | |
Biological Process | mRNA transport | |
Biological Process | negative regulation of mitochondrial RNA catabolic process | |
Biological Process | regulation of mitochondrial translation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLeucine-rich PPR motif-containing protein, mitochondrial
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ5SGE0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-77 | Mitochondrion | ||||
Sequence: MSALLRPARWLLGAAAVPRLPLSLRLPAGGPGRLPSVVRVAAAGGRPAAGELLSQARLYAIVAEKKDLPEEPAPVRR | ||||||
Chain | PRO_0000295547 | 78-1392 | Leucine-rich PPR motif-containing protein, mitochondrial | |||
Sequence: SGSQFDWALMRLDNSVRRTGRITKGLLQKVFESTCRSGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGTVYDVSHYNALLKVYLQNEYRFSPTDFLAKMEGANIQPNRVTYQRLIAAYCSVGDIEGASKILGFMKTRDLPITEAVFSALVTGHARAGDMESAENILTVMKQAGIEPGPDTYLALLNAHAEKGDIDHVKQILEKVEKSDHYFMDRDFLQIIVSFSKAGYPQYVSEILEKITYERRSIPDAMNLILLLVTEKLEDTAFQVLLALPLARDETSSSFGSFFLRHCVTMDTPAEKLIDYCKRLRDAKVHSSSLQFTLHCALQANKTALAKAVMEALRDEGFPIRTHYFWPLLVGHQKTKNVQGIIDILKIMKEMGVDPDQETYINYVFPCFGSVQSARAALQENKCLPKSTTFAQAEVRNEAINGNLQNILSFLESNALPFSFNSLRGSLILGFRRSMNIDLWSKITELLYKDDRYCQKPPGPTEAVGYFLYNLIDSMSDSEVQAKEERLRQYFHQLREMNVKVSENIYKGICNLLDNYHVPELIKDVKVLVDREKIDSRKTSQFTSSDLESTLEKLKAEGHPVGDPLKQLILLLCSEENMQKALEVKAKYESDMVIGGYAALINLCCRHDNAEDALNLKQEFDRLDPSAVLDTAKYVALVKVLGKHGRVQDAINILKEMKEKDVVIKDAAVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLEKDDLPAALEASIACHEKYKVLPRIHDVLCKLIEKGETDLIQKAMDFVSQEQGEMSMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTEKLFECDRDQMYYNLLKLYKISGDWQRADAVWNKMQEENLIPRERTLRLLAGILKTSNQEVPFDVPELWFGDDRSSLSSSSPSAGDTVTEKMLLSDCRLKKSKDAYNIFLKAEKQDVVFSSEAYSTLVGLLLSKDDFTRAMHVKDFAETHIKGFTLNGAASSLLIIAQVRRDYLKVALETLKAALDLEQVPSELAVTRLIQALALQGDVKSIETIQKMVKGLDAIELSRMVFINNIALAQMKNNEIDAAIENIEHMLASENQTVEHQYFGLSYLFRKVIEEQMEPALEKLSIMSERLANQFALYKPVTDLFLQLVDSGKVDEARALLERCGAIAEQTSILSVFCLRTSQKPKKAPVLKTLLELIPELRENDRVYSCSMKSYVADKDVASAKALYEHLTAKNMKLDDLFLKRYASLLKDVGEPVPFTEPPESFGFYIKQLKEARENPS | ||||||
Modified residue | 151 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 186 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 291 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 462 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 749 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 1025 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1026 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1028 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1137 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed. Expressed in liver, brain and a subset of small diameter sensory neurons in the dorsal root ganglion (at protein level).
Induction
Induced by NGF in nociceptors.
Interaction
Subunit
Component of mRNP complexes associated with HNRPA1 (By similarity).
Component of the complex, at least composed of LRPPRC, BECN1 and BCL2; the interactions prevent BECN1 from forming an autophagy-inducing complex with PIK3C3 (By similarity).
Interacts with CECR2, HEBP2, MAP1S, UXT, PPARGC1A and FOXO1. Interacts (via N-terminus) with EIF4E; the interaction promotes association of EIF4E with 4ESE-containing mRNAs (By similarity).
Interacts with exportin XPO1/CRM1; interacts both alone and in complex with EIF4E and 4ESE-containing mRNAs to form an EIF4E-dependent mRNA export complex (By similarity).
Interacts with importin IPO8; the interaction occurs when LRPPRC is in its RNA-free form and returns LRPPRC to the nucleus for further export rounds (By similarity).
Interacts with BECN1 (By similarity).
Component of the complex, at least composed of LRPPRC, BECN1 and BCL2; the interactions prevent BECN1 from forming an autophagy-inducing complex with PIK3C3 (By similarity).
Interacts with CECR2, HEBP2, MAP1S, UXT, PPARGC1A and FOXO1. Interacts (via N-terminus) with EIF4E; the interaction promotes association of EIF4E with 4ESE-containing mRNAs (By similarity).
Interacts with exportin XPO1/CRM1; interacts both alone and in complex with EIF4E and 4ESE-containing mRNAs to form an EIF4E-dependent mRNA export complex (By similarity).
Interacts with importin IPO8; the interaction occurs when LRPPRC is in its RNA-free form and returns LRPPRC to the nucleus for further export rounds (By similarity).
Interacts with BECN1 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 125-159 | PPR 1 | ||||
Sequence: LLRSCGSLLPELSLAERTEFAHKIWDKLQQLGTVY | ||||||
Repeat | 160-194 | PPR 2 | ||||
Sequence: DVSHYNALLKVYLQNEYRFSPTDFLAKMEGANIQP | ||||||
Repeat | 195-229 | PPR 3 | ||||
Sequence: NRVTYQRLIAAYCSVGDIEGASKILGFMKTRDLPI | ||||||
Repeat | 230-264 | PPR 4 | ||||
Sequence: TEAVFSALVTGHARAGDMESAENILTVMKQAGIEP | ||||||
Repeat | 265-299 | PPR 5 | ||||
Sequence: GPDTYLALLNAHAEKGDIDHVKQILEKVEKSDHYF | ||||||
Repeat | 300-334 | PPR 6 | ||||
Sequence: MDRDFLQIIVSFSKAGYPQYVSEILEKITYERRSI | ||||||
Repeat | 402-436 | PPR 7 | ||||
Sequence: HSSSLQFTLHCALQANKTALAKAVMEALRDEGFPI | ||||||
Repeat | 437-471 | PPR 8 | ||||
Sequence: RTHYFWPLLVGHQKTKNVQGIIDILKIMKEMGVDP | ||||||
Repeat | 677-708 | PPR 9 | ||||
Sequence: VGDPLKQLILLLCSEENMQKALEVKAKYESDM | ||||||
Repeat | 709-745 | PPR 10 | ||||
Sequence: VIGGYAALINLCCRHDNAEDALNLKQEFDRLDPSAVL | ||||||
Repeat | 746-783 | PPR 11 | ||||
Sequence: DTAKYVALVKVLGKHGRVQDAINILKEMKEKDVVIKDA | ||||||
Repeat | 784-820 | PPR 12 | ||||
Sequence: AVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPS | ||||||
Repeat | 821-856 | PPR 13 | ||||
Sequence: SNISFPLVTVHLEKDDLPAALEASIACHEKYKVLPR | ||||||
Repeat | 953-987 | PPR 14 | ||||
Sequence: RDQMYYNLLKLYKISGDWQRADAVWNKMQEENLIP | ||||||
Repeat | 1030-1064 | PPR 15 | ||||
Sequence: GDTVTEKMLLSDCRLKKSKDAYNIFLKAEKQDVVF | ||||||
Repeat | 1065-1101 | PPR 16 | ||||
Sequence: SSEAYSTLVGLLLSKDDFTRAMHVKDFAETHIKGFTL | ||||||
Repeat | 1102-1136 | PPR 17 | ||||
Sequence: NGAASSLLIIAQVRRDYLKVALETLKAALDLEQVP | ||||||
Repeat | 1137-1173 | PPR 18 | ||||
Sequence: SELAVTRLIQALALQGDVKSIETIQKMVKGLDAIELS | ||||||
Repeat | 1174-1208 | PPR 19 | ||||
Sequence: RMVFINNIALAQMKNNEIDAAIENIEHMLASENQT | ||||||
Repeat | 1315-1349 | PPR 20 | ||||
Sequence: NDRVYSCSMKSYVADKDVASAKALYEHLTAKNMKL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,392
- Mass (Da)156,653
- Last updated2004-12-21 v1
- Checksum80D6040F4671D097
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1LM33 | F1LM33_RAT | Lrpprc | 1398 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY293808 EMBL· GenBank· DDBJ | AAQ74626.1 EMBL· GenBank· DDBJ | mRNA |