Q5RJF7 · CA2D4_MOUSE

  • Protein
    Voltage-dependent calcium channel subunit alpha-2/delta-4
  • Gene
    Cacna2d4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.

Features

Showing features for binding site.

111161002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site276a divalent metal cation (UniProtKB | ChEBI)
Binding site278a divalent metal cation (UniProtKB | ChEBI)
Binding site280a divalent metal cation (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity

Keywords

Names & Taxonomy

Protein names

Gene names

    • Name
      Cacna2d4

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5RJF7

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain48-1094Extracellular
Transmembrane1095-1115Helical
Topological domain1116Cytoplasmic

Keywords

Phenotypes & Variants

Involvement in disease

  • Defects in Cacna2d4 are a cause of cone-rod dysfunction. Mice display affected retinal ribbon-type synapses. The retinopathy is accompanied by a substantial loss in the activities of the second-order neurons. Rod photoreceptor responses are maintained with reduced amplitude, whereas cone activities are absent

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 59 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-47
ChainPRO_000030465948-970Voltage-dependent calcium channel subunit alpha-2-4
ChainPRO_000030465848-1116Voltage-dependent calcium channel subunit alpha-2/delta-4
Glycosylation180N-linked (GlcNAc...) asparagine
Disulfide bond426↔1076Interchain (between alpha-2-4 and delta-4 chains)
Glycosylation643N-linked (GlcNAc...) asparagine
Glycosylation725N-linked (GlcNAc...) asparagine
ChainPRO_0000304660971-1116Voltage-dependent calcium channel subunit delta-4

Post-translational modification

May be proteolytically processed into subunits alpha-2-4 and delta-4 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (Probable). Interacts with CACNA1C and CACNB3 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain270-452VWFA
Motif276-280MIDAS-like motif
Domain466-559Cache

Domain

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q5RJF7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,116
  • Mass (Da)
    125,991
  • Last updated
    2004-12-21 v1
  • Checksum
    731AE2A4B090B143
MARCPMLSSSHNQDHSGRWTAVWTSLWKTPIILWLLLSDTSLPTVRGQTTVPLETVKLWADTFGRNLYNTVTRYSGSLLLQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRRKVEAVESLVEAAEEADLNHEFNASLVFNYYNSVLINEKDDKGNYVELGAEFLLESDAHFSNLRVNVSMSSVQLPTNVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYPGIKWMPDENGVIAFDCRNRGWYIQAATSPKDIVILVDISGSMKGLRMAIAKHTITTILDTLGENDFVNIIAYNDYVHYIEPCFKGILVQADRDNREHFKQLVDELMVKGVGVVSQALIEAFEILKQFQESKQGSLCNQAIMLITDGAVEDYEPVFETYNWPDRKVRVFTYLIGREVTFADRMKWIACNNKGYYTQISTLADAQESVMEYLHVLSRPMVINHDHDIIWTEAYMDSRLFTSEAQSLMLLTTVAMPVFSKKNETRSHGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLRPKPNYNSVDLSEVEWEDQAEILRTAMINGETGSHSMDVKVPLDKGKRVLFLTNDYFFTDISDTPFSLGVVLTRGHGEYILLGNTSVEEGLHDLLHPDLTLASDWIYCITDIDPDHRKLSQLEAVVRFLTGVDPDLECDEELVREVLFDAVVTAPMEAYWTALALNISEESEPGVDVAFLGTRAGLLRRSLFVGSEKVSDRKFLTPEDEASIFTMDHFPLWYRQASEQPPGSFVFNLRWAEGPDSPGKPVAVRASTAVTVTVDGKTAIAAAVGIQMQADYLQRQFWAAMQQCNAVEGPCLKSCEDTDLDCFVIDNNGFVLISERPQEMGRLLGEADGALMKQLLSMGVFSRVTMYDYQAMCKPPDHHHSAAESLFSPLSAFLMVARWLLHECLLFLLEWSAWGSWQDKGSEAKSVFHHSHKHKKQDLLHPCDTEYPVFVHQTAIQEANGIIECGGCQKTFVMQQIPRSNLLLLVTDRTCDCSAHSPILQEATEVKYNASVKCDRMRSQKPRRRPGSCHAFHPEENAQDCGGASDTLPSSPLLLLSLGAWLLPPQLLW

Q5RJF7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F8VPL1F8VPL1_MOUSECacna2d41144

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_044323528-552in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC115816
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BK005394
EMBL· GenBank· DDBJ
DAA05529.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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