Q5RHD1 · KDM7A_DANRE

Function

function

Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site.

1875100200300400500600700800
TypeIDPosition(s)Description
Binding site246substrate
Binding site249Fe cation (UniProtKB | ChEBI); catalytic
Binding site251Fe cation (UniProtKB | ChEBI); catalytic
Binding site266substrate
Binding site321Fe cation (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Function2-oxoglutarate-dependent dioxygenase activity
Molecular Functionhistone demethylase activity
Molecular Functionhistone H3K27me2/H3K27me3 demethylase activity
Molecular Functionhistone H3K36 demethylase activity
Molecular Functionhistone H3K9 demethylase activity
Molecular Functionhistone H4K20 demethylase activity
Molecular Functionmetal ion binding
Molecular Functiontranscription coregulator activity
Biological Processmidbrain development
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysine-specific demethylase 7A
  • EC number
  • Short names
    DrKDM7a
  • Alternative names
    • JmjC domain-containing histone demethylation protein 1D-A

Gene names

    • Name
      kdm7a
    • Synonyms
      jhdm1da, kdm7
    • ORF names
      si:dkey-105o6.2

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q5RHD1
  • Secondary accessions
    • A5PL83

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003942491-875Lysine-specific demethylase 7A

Proteomic databases

Expression

Tissue specificity

Predominantly expressed in brain.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, domain, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger5-56PHD-type
Domain197-353JmjC
Region442-506Disordered
Compositional bias450-469Polar residues
Compositional bias477-505Basic residues
Compositional bias629-652Polar residues
Region629-710Disordered
Compositional bias653-673Basic and acidic residues
Compositional bias742-759Polar residues
Region742-820Disordered
Compositional bias797-811Polar residues

Domain

The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2 (By similarity).

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    875
  • Mass (Da)
    98,827
  • Last updated
    2010-05-18 v2
  • Checksum
    B257F3649D95AFF4
MAAAPLYCVCRQPYDVNRFMIECDICKDWFHGSCVQVVEHHAADIDVYHCPNCEPIHGPYMMKKHNNWHRHDYTEPNDGTRPVQAGTAVFVKELQARSFASGDILVQMQGNQVTKRFLEKEGFNYPIVVHDLDGLGLKLPPPSFSVSDVEHYVGANKVIDVIDVAKQADSKMKLGEFVKYYYQPERPKVLNVISLEFSDTRMSNLVVVPDIAQKMSWVENYWPDDSFFPKPFVQKYCLMGMKNSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTKANLALYEAWSSSPNQSEVFFGEKVDKCYKCVVKQGTTILLPTGWIHAVLTSQDSMAFGGNFLHNLNIDMQLRCYEMERRLKTPDLFKFPYFEAICWYVAKNLLETLKELRENKCEAQGFLVNGVKALISSLKMWLRRELTQPNSEVPDNIRPGHLIKALSKEIRHLEDDSNKAVKTQGSAECSLSRSTLEKGDQAQQAARRLQDHHHHRRRHHHHHHHHHHHHHHHHSRKLPSNLDVLELHTLEVLKRLEVGQLKEDSAFSSKVNGKFKKVCPVPAAAVEASHDNALRLVMCNGKIIRERMPITNVAATVNAVEMYHKHRIKLERIPMCPEEKVKKEKCEDEFGVQCTIKKPVSQGESVQTELRTESPHLASSDSDSKAGDSAEKCSLESESSDGEDGGSQRDSGTFVEHLNSHRHSHHKQALKRERPTSPNTDCAIQGMLSMAGLLCPQASGGAADILQQRWWASQGNGSSTSSSSDMWDSSEPCSAPRSPDAEDGSLGEEYSYRESSLSPPLHPSKRHAPNPTPVSNQATKGKRPKKGQATAKQRLGKILKMSRHKGLFLMKPMVFLIPQQGGTPLDPQFLLQSSSICVFPPPLIVSG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8RKB3A0A2R8RKB3_DANREkdm7aa837

Sequence caution

The sequence AAI42783.1 differs from that shown. Reason: Miscellaneous discrepancy Contaminating sequence. Potential poly-A sequence.
The sequence CAI12074.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict182in Ref. 2; AAI42783
Compositional bias450-469Polar residues
Sequence conflict454in Ref. 2; AAI42783
Sequence conflict471in Ref. 2; AAI42783
Compositional bias477-505Basic residues
Sequence conflict588in Ref. 2; AAI42783
Sequence conflict596in Ref. 2; AAI42783
Compositional bias629-652Polar residues
Compositional bias653-673Basic and acidic residues
Compositional bias742-759Polar residues
Compositional bias797-811Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX537168
EMBL· GenBank· DDBJ
CAI12074.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BC142782
EMBL· GenBank· DDBJ
AAI42783.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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