Q5RG45 · CP135_DANRE
- ProteinCentrosomal protein of 135 kDa
- Genecep135
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1164 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Centrosomal microtubule-binding protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 103 | Microtubule binding | |||
Site | 106 | Microtubule binding | |||
Site | 110 | Microtubule binding | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centriole | |
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Biological Process | centriole replication |
Names & Taxonomy
Protein names
- Recommended nameCentrosomal protein of 135 kDa
- Short namesCep135
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ5RG45
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000307124 | 1-1164 | Centrosomal protein of 135 kDa | ||
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 13-66 | Homodimerization | |||
Coiled coil | 77-153 | ||||
Coiled coil | 202-423 | ||||
Coiled coil | 454-649 | ||||
Region | 475-505 | Disordered | |||
Coiled coil | 673-1041 | ||||
Coiled coil | 1084-1118 | ||||
Compositional bias | 1121-1144 | Polar residues | |||
Region | 1121-1164 | Disordered | |||
Domain
Coiled-coil domains are critical for microtubule binding via the formation of a two-stranded coiled-coil structure in homodimers.
Sequence similarities
Belongs to the CEP135/TSGA10 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,164
- Mass (Da)134,956
- Last updated2007-04-03 v2
- ChecksumB1FCEE379964CFE2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2B7F9 | A0A8M2B7F9_DANRE | cep135 | 1170 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1121-1144 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR352243 EMBL· GenBank· DDBJ | CAI21313.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX294157 EMBL· GenBank· DDBJ | CAI21313.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX294157 EMBL· GenBank· DDBJ | CAM56389.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CR352243 EMBL· GenBank· DDBJ | CAM56389.1 EMBL· GenBank· DDBJ | Genomic DNA |