Q5RFG3 · GPX3_PONPY

Function

function

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Catalytic activity

Features

Showing features for active site.

122620406080100120140160180200220
TypeIDPosition(s)Description
Active site73

GO annotations

AspectTerm
Cellular Componentextracellular space
Molecular Functionglutathione peroxidase activity
Molecular Functionidentical protein binding
Molecular Functionselenium binding
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione peroxidase 3
  • EC number
  • Short names
    GPx-3; GSHPx-3
  • Alternative names
    • Plasma glutathione peroxidase (GPx-P; GSHPx-P)

Gene names

    • Name
      GPX3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo

Accessions

  • Primary accession
    Q5RFG3

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000004261525-226Glutathione peroxidase 3

Expression

Tissue specificity

Secreted in plasma.

Interaction

Subunit

Homotetramer.

Family & Domains

Sequence similarities

Belongs to the glutathione peroxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    226
  • Mass (Da)
    25,562
  • Last updated
    2008-02-26 v3
  • Checksum
    D7F77A1692493D98
MARLLQASCLLSLLLAGFVPQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK

Features

Showing features for non-standard residue.

TypeIDPosition(s)Description
Non-standard residue73Selenocysteine

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB121006
EMBL· GenBank· DDBJ
BAE17014.1
EMBL· GenBank· DDBJ
mRNA
CR857195
EMBL· GenBank· DDBJ
CAH89494.2
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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