Q5RFD2 · S47A1_PONAB
- ProteinMultidrug and toxin extrusion protein 1
- GeneSLC47A1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids570 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Multidrug efflux pump that functions as a H+/organic cation antiporter. Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively. Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier.
Miscellaneous
Mediates the efflux of cationic compounds such as the model cations, tetraethylammonium (TEA), the neurotoxin 1-methyl-4-phenylpyridinium (MPP), the platinum-based drugs cisplatin and oxaliplatin, the drugs procainamide, acyclovir and topotecan, or weak bases that are positively charged at physiological pH, such as cimetidine or the antidiabetic drug metformin.
Catalytic activity
- H+(in) + thiamine(out) = H+(out) + thiamine(in)
- estrone 3-sulfate(in) + H+(out) = estrone 3-sulfate(out) + H+(in)
- creatinine(in) + H+(out) = creatinine(out) + H+(in)
- agmatine(in) + H+(out) = agmatine(out) + H+(in)This reaction proceeds in the forward and the backward directions.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | organic cation transmembrane transporter activity | |
Molecular Function | putrescine transmembrane transporter activity | |
Molecular Function | thiamine transmembrane transporter activity | |
Molecular Function | xenobiotic transmembrane transporter activity | |
Biological Process | organic cation transport | |
Biological Process | putrescine transport | |
Biological Process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMultidrug and toxin extrusion protein 1
- Short namesMATE-1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionQ5RFD2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Apical cell membrane ; Multi-pass membrane protein
Note: Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-37 | Cytoplasmic | ||||
Sequence: MEAPEEPAPVRGGPEATLEIHGSRFLRLSAFREELRA | ||||||
Transmembrane | 38-58 | Helical | ||||
Sequence: LLVLAGPAFLVQLMVFLISFI | ||||||
Topological domain | 59-72 | Extracellular | ||||
Sequence: SSVFCGHLGKLELD | ||||||
Transmembrane | 73-93 | Helical | ||||
Sequence: AVTLAIAVINVTGVSVGFGLS | ||||||
Topological domain | 94-120 | Cytoplasmic | ||||
Sequence: SACDTLISQTYGSQNLKHVGVILQRSA | ||||||
Transmembrane | 121-141 | Helical | ||||
Sequence: LILLLCCFPCWALFLNTQHIL | ||||||
Topological domain | 142-152 | Extracellular | ||||
Sequence: LLFRQDPDVSR | ||||||
Transmembrane | 153-173 | Helical | ||||
Sequence: LTQTYVTIFIPALPATFLYML | ||||||
Topological domain | 174-176 | Cytoplasmic | ||||
Sequence: QVK | ||||||
Transmembrane | 177-197 | Helical | ||||
Sequence: YLLNQGIVLPQIVTGVAANLV | ||||||
Topological domain | 198-216 | Extracellular | ||||
Sequence: NALANYLFLHQLHLGAIGS | ||||||
Transmembrane | 217-237 | Helical | ||||
Sequence: ALANLISQYTLALLLFFYILG | ||||||
Topological domain | 238-251 | Cytoplasmic | ||||
Sequence: KKLHQATWGGWSLE | ||||||
Transmembrane | 252-272 | Helical | ||||
Sequence: CLQDWASFLHLAVPSMLMLCM | ||||||
Topological domain | 273-295 | Extracellular | ||||
Sequence: EWWAYEVGSFLSGILGMVELGAQ | ||||||
Transmembrane | 296-316 | Helical | ||||
Sequence: SIVYELAIIVYMVPAGFSVAA | ||||||
Topological domain | 317-336 | Cytoplasmic | ||||
Sequence: SVRVGNALGAGDMEQARKSS | ||||||
Transmembrane | 337-357 | Helical | ||||
Sequence: TVSLLITVLFAVAFSVLLLSC | ||||||
Topological domain | 358-370 | Extracellular | ||||
Sequence: KDHVGYIFTTDRD | ||||||
Transmembrane | 371-391 | Helical | ||||
Sequence: IINLVAQVVPIYAVSHLFEAL | ||||||
Topological domain | 392-408 | Cytoplasmic | ||||
Sequence: ACTSGGVLRGSGNQKVG | ||||||
Transmembrane | 409-429 | Helical | ||||
Sequence: AIVNTIGYYVVGLPIGIALMF | ||||||
Topological domain | 430-437 | Extracellular | ||||
Sequence: ATKLGVMG | ||||||
Transmembrane | 438-458 | Helical | ||||
Sequence: LWSGIIICTVFQAVCFLGFII | ||||||
Topological domain | 459-546 | Cytoplasmic | ||||
Sequence: QLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGETQSDQQMRQEEPLPEHPQDSAKLSRKQLVLRR | ||||||
Transmembrane | 547-567 | Helical | ||||
Sequence: GLLLLGVFLILLVGILVRFYV | ||||||
Topological domain | 568-570 | Extracellular | ||||
Sequence: RIQ |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000312847 | 1-570 | Multidrug and toxin extrusion protein 1 | |||
Sequence: MEAPEEPAPVRGGPEATLEIHGSRFLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALILLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGAIGSALANLISQYTLALLLFFYILGKKLHQATWGGWSLECLQDWASFLHLAVPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATKLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGETQSDQQMRQEEPLPEHPQDSAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 508-534 | Disordered | ||||
Sequence: DVGKTGETQSDQQMRQEEPLPEHPQDS |
Sequence similarities
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length570
- Mass (Da)62,009
- Last updated2004-12-21 v1
- Checksum6DE41106E9353BE8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR857226 EMBL· GenBank· DDBJ | CAH89525.1 EMBL· GenBank· DDBJ | mRNA |