Q5REZ7 · Q5REZ7_PONAB
- Protein4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- GeneDKFZp469C2232
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids266 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the final step in the metabolic pathway of hydroxyproline.
Catalytic activity
- (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 107 | Proton donor/acceptor | |||
Active site | 135 | Schiff-base intermediate with substrate | |||
Binding site | 178 | pyruvate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | (R,S)-4-hydroxy-2-oxoglutarate aldolase activity | |
Biological Process | glyoxylate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionQ5REZ7
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusFragment
- Length266
- Mass (Da)28,750
- Last updated2004-12-21 v1
- Checksum75F810D6BE50F608
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR857365 EMBL· GenBank· DDBJ | CAH89660.1 EMBL· GenBank· DDBJ | mRNA |