Q5RDI5 · Q5RDI5_PONAB
- Proteinreceptor protein-tyrosine kinase
- GeneDKFZp469E064
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1123 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 830-837 | ATP (UniProtKB | ChEBI) | |||
Binding site | 854 | ATP (UniProtKB | ChEBI) | |||
Active site | 963 | Proton acceptor | |||
Binding site | 967 | ATP (UniProtKB | ChEBI) | |||
Binding site | 968 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 981 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | angiogenesis | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | endothelial cell proliferation | |
Biological Process | positive regulation of angiogenesis | |
Biological Process | positive regulation of endothelial cell migration | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionQ5RDI5
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 746-770 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5004262466 | 23-1123 | receptor protein-tyrosine kinase | ||
Disulfide bond | 242↔251 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 216-252 | EGF-like | |||
Domain | 350-440 | Ig-like | |||
Domain | 447-541 | Fibronectin type-III | |||
Domain | 545-636 | Fibronectin type-III | |||
Domain | 641-735 | Fibronectin type-III | |||
Domain | 823-1095 | Protein kinase | |||
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,123
- Mass (Da)125,654
- Last updated2004-12-21 v1
- ChecksumE27ECC3E1E3EF9C9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR857924 EMBL· GenBank· DDBJ | CAH90172.1 EMBL· GenBank· DDBJ | mRNA |