Q5RDB0 · Q5RDB0_PONAB
- Proteinreceptor protein-tyrosine kinase
- GeneDKFZp469L125
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1124 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 831-838 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GEGNFGQV | ||||||
Binding site | 855 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 964 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 968 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 969 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 982 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | angiogenesis | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | endothelial cell proliferation | |
Biological Process | positive regulation of angiogenesis | |
Biological Process | positive regulation of endothelial cell migration | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionQ5RDB0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 746-770 | Helical | ||||
Sequence: MLLIAILGSAGMTCLTVLLAFLIIL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MDSLASLVLCGVSLLPSGTVEG | ||||||
Chain | PRO_5004261689 | 23-1124 | receptor protein-tyrosine kinase | |||
Sequence: AMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLLRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKIFNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDTAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPLFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA | ||||||
Disulfide bond | 242↔251 | |||||
Sequence: CPPGFMGRTC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 216-252 | EGF-like | ||||
Sequence: WGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCE | ||||||
Domain | 350-440 | Ig-like | ||||
Sequence: PKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNIS | ||||||
Domain | 447-541 | Fibronectin type-III | ||||
Sequence: PLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLLRRGEGGEGHPGPVRRFTTASI | ||||||
Domain | 545-636 | Fibronectin type-III | ||||
Sequence: PPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSD | ||||||
Domain | 641-735 | Fibronectin type-III | ||||
Sequence: QPENIKIFNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPES | ||||||
Domain | 824-1096 | Protein kinase | ||||
Sequence: IKFQDVIGEGNFGQVLKARIKKDGLRMDTAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPLFAQILVSLNRML |
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,124
- Mass (Da)125,927
- Last updated2004-12-21 v1
- ChecksumA771C45B94F09AA2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR858004 EMBL· GenBank· DDBJ | CAH90247.1 EMBL· GenBank· DDBJ | mRNA |