Q5RBM6 · BUP1_PONAB

Function

function

Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide.

Catalytic activity

Pathway

Amino-acid biosynthesis; beta-alanine biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site119Proton acceptor
Active site196Proton donor
Active site233Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionbeta-ureidopropionase activity
Biological Processbeta-alanine biosynthetic process via 3-ureidopropionate
Biological Processprotein homooligomerization
Biological Processpyrimidine nucleoside catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-ureidopropionase
  • EC number
  • Alternative names
    • Beta-alanine synthase
    • N-carbamoyl-beta-alanine amidohydrolase

Gene names

    • Name
      UPB1

Organism names

Accessions

  • Primary accession
    Q5RBM6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002040531-384Beta-ureidopropionase
Modified residue378Phosphoserine

Keywords

Interaction

Subunit

Homodimer, homotetramer, homooctamer; can also form higher homooligomers.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain72-344CN hydrolase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    384
  • Mass (Da)
    43,098
  • Last updated
    2004-12-21 v1
  • Checksum
    8F7B1BC8E25077BA
MAGAEWKSLEECLEKHLPLPDLQEVKRVLYGKELRKLDLPREAFEAASREDFELQGYAFEAAEEQLRRPRIVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQEAWTMPFAFCTREKLPWTEFAESAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLWNTAVVISNSGAVLGKTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSINGAEIIFNPSATIGALSESLWSIEARNAAIANHCFTCAINRVGTEHFPNEFTSGDGKKAHQDFGYFYGSSYVAAPDGSRTPGLSRSQDGLLVAKLDLNLCQQVNDVWNFKMTGRYEMYARELAEAVKSNYSPTIVKE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR858612
EMBL· GenBank· DDBJ
CAH90834.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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