Q5R981 · CMTR1_PONAB

Function

function

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m7GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m7GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

Features

Showing features for binding site, active site.

1835100200300400500600700800
TypeIDPosition(s)Description
Binding site203-207substrate
Binding site218substrate
Binding site234S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site239
Binding site277-283S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site335-336S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site364
Binding site374-376substrate
Active site404Proton acceptor
Binding site439substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular Functionnucleic acid binding
Biological Process7-methylguanosine mRNA capping
Biological Processmethylation
Biological ProcessmRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
  • EC number
  • Alternative names
    • Cap methyltransferase 1
    • Cap1 2'O-ribose methyltransferase 1 (MTr1)
    • FtsJ methyltransferase domain-containing protein 2

Gene names

    • Name
      CMTR1
    • Synonyms
      FTSJD2

Organism names

Accessions

  • Primary accession
    Q5R981

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002512411-835Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Modified residue28Phosphoserine
Modified residue31Phosphoserine
Modified residue53Phosphoserine
Modified residue66Phosphoserine
Modified residue91Phosphoserine
Modified residue108N6-acetyllysine

Keywords

Interaction

Subunit

Interacts with POLR2A (via C-terminus).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, motif, domain.

TypeIDPosition(s)Description
Compositional bias1-21Basic and acidic residues
Region1-67Disordered
Motif2-19Bipartite nuclear localization signal
Compositional bias23-57Polar residues
Domain87-133G-patch
Domain231-450RrmJ-type SAM-dependent 2'-O-MTase
Region727-835Interaction with POLR2A
Domain752-786WW

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    835
  • Mass (Da)
    95,321
  • Last updated
    2004-12-21 v1
  • Checksum
    03919512A73C30FB
MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H2PIW9H2PIW9_PONABCMTR1804

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-21Basic and acidic residues
Compositional bias23-57Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR859510
EMBL· GenBank· DDBJ
CAH91679.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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