Q5R4R6 · SRP54_PONAB

Function

function

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).
As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity).
Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity).
Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity).
Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity).
SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity).
Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site108-115GTP (UniProtKB | ChEBI)
Binding site190-194GTP (UniProtKB | ChEBI)
Binding site248-251GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentnuclear speck
Cellular Componentnucleus
Cellular Componentsignal recognition particle, endoplasmic reticulum targeting
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular Functionendoplasmic reticulum signal peptide binding
Molecular FunctionGDP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribonucleoprotein complex binding
Biological Processexocrine pancreas development
Biological Processgranulocyte differentiation
Biological Processneutrophil chemotaxis
Biological Processprotein targeting to ER
Biological ProcessSRP-dependent cotranslational protein targeting to membrane, translocation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle subunit SRP54
  • EC number
  • Alternative names
    • Signal recognition particle 54 kDa protein

Gene names

    • Name
      SRP54

Organism names

Accessions

  • Primary accession
    Q5R4R6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001011951-504Signal recognition particle subunit SRP54

Interaction

Subunit

Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity).
Interacts with RNPS1 (By similarity).
Interacts with the SRP receptor subunit SRPRA (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-295NG-domain
Region296-504M-domain

Domain

The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity).
The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity).
SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    504
  • Mass (Da)
    55,705
  • Last updated
    2004-12-21 v1
  • Checksum
    7D7630A43BC5EC2C
MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2J8TI59A0A2J8TI59_PONABSRP54455
A0A2J8TI72A0A2J8TI72_PONABSRP5453
H2NL06H2NL06_PONABSRP54481

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR861178
EMBL· GenBank· DDBJ
CAH93250.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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