Q5R4M6 · SCG2_PONAB
- ProteinSecretogranin-2
- GeneSCG2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids617 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
Miscellaneous
Binds calcium with a low-affinity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | secretory granule | |
Molecular Function | chemoattractant activity | |
Molecular Function | cytokine activity | |
Biological Process | angiogenesis | |
Biological Process | eosinophil chemotaxis |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSecretogranin-2
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionQ5R4M6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Neuroendocrine and endocrine secretory granules.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, propeptide, chain, modified residue, peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MAEAKTHWLGAALSLIPLIFLISGAEA | ||||||
Propeptide | PRO_0000352524 | 28-30 | ||||
Sequence: ASF | ||||||
Chain | PRO_0000352525 | 31-617 | Secretogranin-2 | |||
Sequence: QRNQLLQKEPDLRLENVKKFPSPEMIRALEYIEKLRQQAHKEESSSDYNPYQGVSVPFQQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMNEENSRDNPFKRTNEIVEEQYAPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNKMLSKSGYPKTPGRAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGPGRSRSNQLPKAAWMPYVENRQMAYENLNDKDQELGEYLARMLVKYPEIISSNQVKRVPGQSSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYLDEDLLMKVLEYLNQEKAEKGREHIAKRAMENM | ||||||
Modified residue | 151 | Sulfotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 174 | Phosphoserine | ||||
Sequence: S | ||||||
Peptide | PRO_0000352526 | 182-214 | Secretoneurin | |||
Sequence: TNEIVEEQYAPQSLATLESVFQELGKLTGPNNQ | ||||||
Modified residue | 268 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 432 | Phosphoserine | ||||
Sequence: S | ||||||
Peptide | PRO_0000432739 | 527-566 | Manserin | |||
Sequence: VPGQSSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVS | ||||||
Modified residue | 532 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 555 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 556 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 68-105 | Disordered | ||||
Sequence: QAHKEESSSDYNPYQGVSVPFQQKENGDESHLPERDSL | ||||||
Compositional bias | 74-92 | Polar residues | ||||
Sequence: SSSDYNPYQGVSVPFQQKE | ||||||
Region | 120-143 | Disordered | ||||
Sequence: QAENEPQSAPKENKPYALNSEKNF | ||||||
Region | 258-290 | Disordered | ||||
Sequence: ESQTQEEVRDSKENIEKNEQINDEMKRSGQLGI | ||||||
Region | 407-427 | Disordered | ||||
Sequence: NKMLSKSGYPKTPGRAGTEAL | ||||||
Region | 551-582 | Disordered | ||||
Sequence: LNQGSSQETDKLAPVSKRFPVGPPKNDDTPNR |
Sequence similarities
Belongs to the chromogranin/secretogranin protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length617
- Mass (Da)70,872
- Last updated2004-12-21 v1
- Checksum7CA6D9A8188242E6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 74-92 | Polar residues | ||||
Sequence: SSSDYNPYQGVSVPFQQKE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR861220 EMBL· GenBank· DDBJ | CAH93290.1 EMBL· GenBank· DDBJ | mRNA |