Q5R1W6 · TKT_PANTR

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site37substrate
Site37Important for catalytic activity
Binding site40thiamine diphosphate (UniProtKB | ChEBI)
Binding site77thiamine diphosphate (UniProtKB | ChEBI)
Binding site123-125thiamine diphosphate (UniProtKB | ChEBI)
Binding site155Mg2+ (UniProtKB | ChEBI)
Binding site156thiamine diphosphate (UniProtKB | ChEBI)
Binding site185Mg2+ (UniProtKB | ChEBI)
Binding site185thiamine diphosphate (UniProtKB | ChEBI)
Binding site187Mg2+ (UniProtKB | ChEBI)
Binding site244thiamine diphosphate (UniProtKB | ChEBI)
Binding site258substrate
Binding site258thiamine diphosphate (UniProtKB | ChEBI)
Site258Important for catalytic activity
Binding site318substrate
Binding site345substrate
Active site366Proton donor
Binding site392thiamine diphosphate (UniProtKB | ChEBI)
Binding site416substrate
Binding site424substrate
Binding site428thiamine diphosphate (UniProtKB | ChEBI)
Binding site474substrate

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionmetal ion binding
Molecular Functionthiamine pyrophosphate binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt, non-oxidative branch

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      TKT

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    Q5R1W6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue, chain, cross-link.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00001918971-623Transketolase
Modified residue6N6-acetyllysine
Modified residue11N6-acetyllysine
Modified residue104Phosphoserine
Modified residue144N6-acetyllysine
Modified residue204N6-acetyllysine
Modified residue232N6-acetyllysine
Modified residue241N6-acetyllysine
Modified residue260N6-acetyllysine
Modified residue275Phosphotyrosine
Modified residue287Phosphothreonine
Modified residue295Phosphoserine
Modified residue345Phosphoserine
Cross-link352Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue538N6-acetyllysine
Modified residue603N6-acetyllysine

Keywords

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the transketolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    623
  • Mass (Da)
    67,840
  • Last updated
    2005-01-04 v1
  • Checksum
    CC41ED5AF9C40DDF
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGVEGKESWHGKPFPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVILKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELLKMFGIDKDAIAQAVRGLITKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB188281
EMBL· GenBank· DDBJ
BAD74032.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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