Q5QW45 · XGPT_IDILO

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site41-425-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site95-1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site96Mg2+ (UniProtKB | ChEBI)
Binding site99guanine (UniProtKB | ChEBI)
Binding site99xanthine (UniProtKB | ChEBI)
Binding site99-103GMP (UniProtKB | ChEBI)
Binding site141-142GMP (UniProtKB | ChEBI)
Binding site142guanine (UniProtKB | ChEBI)
Binding site142xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • Ordered locus names
      IL0887

Organism names

Accessions

  • Primary accession
    Q5QW45

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001396741-161Xanthine-guanine phosphoribosyltransferase

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    18,408
  • Last updated
    2005-01-04 v1
  • MD5 Checksum
    7E0E91009ABA6730000780EAAE220DA8
MGWHSNREFFVSWEELHRATRELARRQLPAEQYKGIIAVSRGGLVPAAIVSRELNIRVVDCVAVSSYDHTEQRDDLQVMKDVTATEDGEGFLVVDDLVDTGNTMKFLRERLPKAKFVTVYAKPSGMEMVDDFVADLAQDTWIHFPWDMHLHYIEPLAGQES

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017340
EMBL· GenBank· DDBJ
AAV81727.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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