Q5QFX2 · Q5QFX2_9MAXI

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Hexanauplia > Copepoda > Calanoida > Calanidae > Calanus

Accessions

  • Primary accession
    Q5QFX2

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-66Helical
Transmembrane86-113Helical
Transmembrane125-149Helical
Transmembrane169-194Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,370
  • Last updated
    2005-01-04 v1
  • Checksum
    6C92594D5EC0326F
TLYLLAGAYSGMIGTGLSMIIRLELGQAGSLIGDDQVYNVVVTAHAFIMIFFMVMPILIGGFGNWLVPLMLGAADMAFPRMNNMSFWFLMPALIMLLSSSLVESGAGTGWTVYPPLSSNVAHAGASVDFAIFSLHLAGVSSILGAVNFISTLGNLRVFGMLLDRMPLFAWAVLITAVLLLLSLPVLAGAITMLLTDRNLNTTFYDVGGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY604518
EMBL· GenBank· DDBJ
AAT99457.1
EMBL· GenBank· DDBJ
Genomic DNA
AY604519
EMBL· GenBank· DDBJ
AAT99458.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305715
EMBL· GenBank· DDBJ
AGD79534.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305716
EMBL· GenBank· DDBJ
AGD79535.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305718
EMBL· GenBank· DDBJ
AGD79537.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305742
EMBL· GenBank· DDBJ
AGD79561.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305743
EMBL· GenBank· DDBJ
AGD79562.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305744
EMBL· GenBank· DDBJ
AGD79563.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305746
EMBL· GenBank· DDBJ
AGD79565.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305747
EMBL· GenBank· DDBJ
AGD79566.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305750
EMBL· GenBank· DDBJ
AGD79569.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305751
EMBL· GenBank· DDBJ
AGD79570.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305752
EMBL· GenBank· DDBJ
AGD79571.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305753
EMBL· GenBank· DDBJ
AGD79572.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305754
EMBL· GenBank· DDBJ
AGD79573.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305755
EMBL· GenBank· DDBJ
AGD79574.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305756
EMBL· GenBank· DDBJ
AGD79575.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305758
EMBL· GenBank· DDBJ
AGD79577.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305759
EMBL· GenBank· DDBJ
AGD79578.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305760
EMBL· GenBank· DDBJ
AGD79579.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305761
EMBL· GenBank· DDBJ
AGD79580.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305762
EMBL· GenBank· DDBJ
AGD79581.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305763
EMBL· GenBank· DDBJ
AGD79582.1
EMBL· GenBank· DDBJ
Genomic DNA
KC305764
EMBL· GenBank· DDBJ
AGD79583.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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