Q5QD16 · TAAR3_MOUSE
- ProteinTrace amine-associated receptor 3
- GeneTaar3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids343 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | trace-amine receptor activity | |
Biological Process | sensory perception of chemical stimulus |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTrace amine-associated receptor 3
- Short namesTaR-3; Trace amine receptor 3; mTaar3
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5QD16
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-35 | Extracellular | ||||
Sequence: MDLIYIPEDLSSCPKFGNKSCPPTNRSFRVRMIMY | ||||||
Transmembrane | 36-56 | Helical; Name=1 | ||||
Sequence: LFMTGAMVITIFGNLVIIISI | ||||||
Topological domain | 57-68 | Cytoplasmic | ||||
Sequence: SHFKQLHSPTNF | ||||||
Transmembrane | 69-89 | Helical; Name=2 | ||||
Sequence: LILSMATTDFLLGFVIMPYSM | ||||||
Topological domain | 90-150 | Extracellular | ||||
Sequence: VRSVESCWYFGDSFCKFHASFDMMLSLTSIFHLCSIAIDRFYAVCDPLHYTTTMTVSMIKR | ||||||
Transmembrane | 151-168 | Helical; Name=3 | ||||
Sequence: LLAFCWAAPALFSFGLVL | ||||||
Topological domain | 169-172 | Cytoplasmic | ||||
Sequence: SEAN | ||||||
Transmembrane | 173-193 | Helical; Name=4 | ||||
Sequence: VSGMQSYEILVACFNFCALTF | ||||||
Topological domain | 194-198 | Extracellular | ||||
Sequence: NKFWG | ||||||
Transmembrane | 199-223 | Helical; Name=5 | ||||
Sequence: TILFTTCFFTPGSIMVGIYGKIFIV | ||||||
Topological domain | 224-257 | Cytoplasmic | ||||
Sequence: SRRHARALSDMPANTKGAVGKNLSKKKDRKAAKT | ||||||
Transmembrane | 258-278 | Helical; Name=6 | ||||
Sequence: LGIVMGVFLACWLPCFLAVLI | ||||||
Topological domain | 279-287 | Extracellular | ||||
Sequence: DPYLDYSTP | ||||||
Transmembrane | 288-308 | Helical; Name=7 | ||||
Sequence: IIVLDLLVWLGYFNSTCNPLI | ||||||
Topological domain | 309-343 | Cytoplasmic | ||||
Sequence: HGFFYPWFRKALQFIVSGKIFRSNSDTANLFPEAH |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070150 | 1-343 | Trace amine-associated receptor 3 | |||
Sequence: MDLIYIPEDLSSCPKFGNKSCPPTNRSFRVRMIMYLFMTGAMVITIFGNLVIIISISHFKQLHSPTNFLILSMATTDFLLGFVIMPYSMVRSVESCWYFGDSFCKFHASFDMMLSLTSIFHLCSIAIDRFYAVCDPLHYTTTMTVSMIKRLLAFCWAAPALFSFGLVLSEANVSGMQSYEILVACFNFCALTFNKFWGTILFTTCFFTPGSIMVGIYGKIFIVSRRHARALSDMPANTKGAVGKNLSKKKDRKAAKTLGIVMGVFLACWLPCFLAVLIDPYLDYSTPIIVLDLLVWLGYFNSTCNPLIHGFFYPWFRKALQFIVSGKIFRSNSDTANLFPEAH | ||||||
Glycosylation | 18 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 25 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 104↔189 | |||||
Sequence: CKFHASFDMMLSLTSIFHLCSIAIDRFYAVCDPLHYTTTMTVSMIKRLLAFCWAAPALFSFGLVLSEANVSGMQSYEILVACFNFC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Specifically expressed in neurons of the olfactory epithelium.
Gene expression databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length343
- Mass (Da)38,745
- Last updated2005-01-04 v1
- Checksum2A3F7D7BFC93AABF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY702327 EMBL· GenBank· DDBJ | AAV70137.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC139171 EMBL· GenBank· DDBJ | AAI39172.1 EMBL· GenBank· DDBJ | mRNA | ||
BC139172 EMBL· GenBank· DDBJ | AAI39173.1 EMBL· GenBank· DDBJ | mRNA |