Q5QD15 · TAAR4_MOUSE
- ProteinTrace amine-associated receptor 4
- GeneTaar4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids347 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 2-phenylethylamine receptor activity | |
Molecular Function | G protein-coupled amine receptor activity | |
Molecular Function | trace-amine receptor activity | |
Biological Process | behavioral fear response | |
Biological Process | chemosensory behavior | |
Biological Process | sensory perception of chemical stimulus |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTrace amine-associated receptor 4
- Short namesTaR-4; Trace amine receptor 4; mTaar4
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5QD15
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-37 | Extracellular | ||||
Sequence: MNTPDPWSSPEVQFCFAAANSSCPRKARPALVVCAMY | ||||||
Transmembrane | 38-58 | Helical; Name=1 | ||||
Sequence: LIMIGAIVMTMLGNMAVIISI | ||||||
Topological domain | 59-69 | Cytoplasmic | ||||
Sequence: AHFKQLHSPTN | ||||||
Transmembrane | 70-90 | Helical; Name=2 | ||||
Sequence: FLILSMATTDFLLSCVVMPFS | ||||||
Topological domain | 91-110 | Extracellular | ||||
Sequence: MIRSIESCWYFGDLFCKVHS | ||||||
Transmembrane | 111-129 | Helical; Name=3 | ||||
Sequence: CCDIMLCTTSIFHLCFISV | ||||||
Topological domain | 130-149 | Cytoplasmic | ||||
Sequence: DRHYAVCDPLHYVTQITTRV | ||||||
Transmembrane | 150-170 | Helical; Name=4 | ||||
Sequence: VGVFLLISWSVPIFFAFGLVF | ||||||
Topological domain | 171-197 | Extracellular | ||||
Sequence: SELNLIGAEDFVAAIDCTGLCVLIFNK | ||||||
Transmembrane | 198-218 | Helical; Name=5 | ||||
Sequence: LWGVLASFIAFFLPGTVMVGI | ||||||
Topological domain | 219-260 | Cytoplasmic | ||||
Sequence: YIHIFTVAQKHARQIGTGPRTKQALSESKMKATSKKESKATK | ||||||
Transmembrane | 261-281 | Helical; Name=6 | ||||
Sequence: TLSIVMGVFVLCWLPFFVLTI | ||||||
Topological domain | 282-296 | Extracellular | ||||
Sequence: TDPFIDFTTPEDLYN | ||||||
Transmembrane | 297-317 | Helical; Name=7 | ||||
Sequence: VFLWLGYFNSTFNPIIYGMFY | ||||||
Topological domain | 318-347 | Cytoplasmic | ||||
Sequence: PWFRKALRMIVTGTIFRSDSSTSSLHPAHP |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice lacking Taar4 show an absence of aversion to low concentrations of volatile amines and to the odor of predator urine.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 31 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070152 | 1-347 | Trace amine-associated receptor 4 | |||
Sequence: MNTPDPWSSPEVQFCFAAANSSCPRKARPALVVCAMYLIMIGAIVMTMLGNMAVIISIAHFKQLHSPTNFLILSMATTDFLLSCVVMPFSMIRSIESCWYFGDLFCKVHSCCDIMLCTTSIFHLCFISVDRHYAVCDPLHYVTQITTRVVGVFLLISWSVPIFFAFGLVFSELNLIGAEDFVAAIDCTGLCVLIFNKLWGVLASFIAFFLPGTVMVGIYIHIFTVAQKHARQIGTGPRTKQALSESKMKATSKKESKATKTLSIVMGVFVLCWLPFFVLTITDPFIDFTTPEDLYNVFLWLGYFNSTFNPIIYGMFYPWFRKALRMIVTGTIFRSDSSTSSLHPAHP | ||||||
Glycosylation | 20 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 106↔191 | |||||
Sequence: CKVHSCCDIMLCTTSIFHLCFISVDRHYAVCDPLHYVTQITTRVVGVFLLISWSVPIFFAFGLVFSELNLIGAEDFVAAIDCTGLC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium.
Gene expression databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)38,904
- Last updated2005-01-04 v1
- ChecksumB1564F458416C9C0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY702328 EMBL· GenBank· DDBJ | AAV70138.1 EMBL· GenBank· DDBJ | Genomic DNA |