Q5PPC4 · Q5PPC4_SUHV
- ProteinDNA polymerase
- GeneUL30
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1048 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.
Catalytic activity
- DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Molecular Function | 3'-5'-DNA exonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Molecular Function | nucleotide binding | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Biological Process | base-excision repair, gap-filling | |
Biological Process | DNA replication proofreading | |
Biological Process | nucleotide-excision repair, DNA gap filling | |
Biological Process | viral DNA genome replication |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA polymerase
- EC number
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Varicellovirus > Varicellovirus suidalpha1
Accessions
- Primary accessionQ5PPC4
Proteomes
Subcellular Location
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 209-443 | DNA-directed DNA polymerase family B exonuclease | ||||
Sequence: THEAGVDATTRLLLDHDLPSFGWYRLRPGPAGERVVLRHQRLTSSDVEVNCTPLNLARDEDGPWPDYKLLCFDIECKAGDDAAFPAAENPEDLVIQISCLLYSLATQRLEHTLLFSLGSCDSDDPAVTVLEFDSEFELLLAFVTFLKQYAPEFATGYNIINFDWAFVHTKLTTVYGLALDGYGRFNRGGQFRVYDAGQNSFQKRSKVKINGLVSLDMYAVAADKLKLPSYKLNAV | ||||||
Domain | 507-988 | DNA-directed DNA polymerase family B multifunctional | ||||
Sequence: ITLARAIYDGQQIRVFTCLLKLAGSRGFVLPDKRRAIADEDDGGGYQGAKVLEPDSGFHVDPVLVLDFASLYPSIIQAHNLCFTTLALARPAGLREDEFSAFEVNGERLYFVHAGVRESLLSILLRDWLAMRKAIRARIPTSAPEEAVLLDKQQAAIKVVCNSVYGFTGVANGLLPCLPVAATVTTIGRDMLVATRDYVQTRWATRELLERDLPARPPAGEYAVRVVYGDTDSVFIRFSGIAYDDVCELGELMAARITRDLFRPPIKLECEKTFRRLLLITKKKYIGVINGGKMLMKGVDLVRKNNCAFINAYARRLVDLLFGDEAVSAAAATIARAPAARWLERPLPRGFAAFGRVLAEAHARVAGGAGLDVADFVMTAELSRPPDAYSNTRLPHLTVYHKLAMRHGEVPSVKERVSYVIIAPTPEAERDAGAVRPGLAPGKLLVSDLAEDPAYVVAHGVPLNTEYYFSHLLSTLSVTFKA |
Sequence similarities
Belongs to the DNA polymerase type-B family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,048
- Mass (Da)115,337
- Last updated2005-01-04 v1
- ChecksumB1EB70CFD389276D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BK001744 EMBL· GenBank· DDBJ | DAA02153.1 EMBL· GenBank· DDBJ | Genomic DNA |