Q5PPC4 · Q5PPC4_SUHV

Function

function

Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.

Catalytic activity

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Molecular Function3'-5'-DNA exonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionnucleotide binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological Processbase-excision repair, gap-filling
Biological ProcessDNA replication proofreading
Biological Processnucleotide-excision repair, DNA gap filling
Biological Processviral DNA genome replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase
  • EC number

Gene names

    • Name
      UL30

Organism names

Accessions

  • Primary accession
    Q5PPC4

Proteomes

Subcellular Location

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain209-443DNA-directed DNA polymerase family B exonuclease
Domain507-988DNA-directed DNA polymerase family B multifunctional

Sequence similarities

Belongs to the DNA polymerase type-B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,048
  • Mass (Da)
    115,337
  • Last updated
    2005-01-04 v1
  • Checksum
    B1EB70CFD389276D
MAARQGSYVTRLSEFKFIAPRCLDAPEQRGVHVGTLAREPTVYCGGATRPILRGEPFWPRRVAAWEGAPERPVSPRFERFHVYDIVESTEYASADPRFPNGTVVTLLGLSACGKRVAVHVYGVRHYFFLGKAEADAALGVASAEQLARALSAAAARGPRLGPADVDARVVDAAPVYYYDAPRRPFYRVSSNSGRLVAHLRETVCAGLVTHEAGVDATTRLLLDHDLPSFGWYRLRPGPAGERVVLRHQRLTSSDVEVNCTPLNLARDEDGPWPDYKLLCFDIECKAGDDAAFPAAENPEDLVIQISCLLYSLATQRLEHTLLFSLGSCDSDDPAVTVLEFDSEFELLLAFVTFLKQYAPEFATGYNIINFDWAFVHTKLTTVYGLALDGYGRFNRGGQFRVYDAGQNSFQKRSKVKINGLVSLDMYAVAADKLKLPSYKLNAVAEEALGERKLDLDYKDIPRYYAAGPRERGVIGRYCVQDSALVGKLFFKFLPHLELSAVARLANITLARAIYDGQQIRVFTCLLKLAGSRGFVLPDKRRAIADEDDGGGYQGAKVLEPDSGFHVDPVLVLDFASLYPSIIQAHNLCFTTLALARPAGLREDEFSAFEVNGERLYFVHAGVRESLLSILLRDWLAMRKAIRARIPTSAPEEAVLLDKQQAAIKVVCNSVYGFTGVANGLLPCLPVAATVTTIGRDMLVATRDYVQTRWATRELLERDLPARPPAGEYAVRVVYGDTDSVFIRFSGIAYDDVCELGELMAARITRDLFRPPIKLECEKTFRRLLLITKKKYIGVINGGKMLMKGVDLVRKNNCAFINAYARRLVDLLFGDEAVSAAAATIARAPAARWLERPLPRGFAAFGRVLAEAHARVAGGAGLDVADFVMTAELSRPPDAYSNTRLPHLTVYHKLAMRHGEVPSVKERVSYVIIAPTPEAERDAGAVRPGLAPGKLLVSDLAEDPAYVVAHGVPLNTEYYFSHLLSTLSVTFKALFGNDTKITERLLKRFIPETAPGDAPFEHEAFAALTGEGGESLQTLRTIFCTPTAAPRRS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BK001744
EMBL· GenBank· DDBJ
DAA02153.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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