Q5PDE6 · SURA_SALPA

Function

function

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentouter membrane-bounded periplasmic space
Molecular Functionpeptide binding
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Molecular Functionunfolded protein binding
Biological ProcessGram-negative-bacterium-type cell outer membrane assembly
Biological Processprotein folding
Biological Processprotein stabilization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Chaperone SurA
  • Alternative names
    • Peptidyl-prolyl cis-trans isomerase SurA
      (PPIase SurA
      ) (EC:5.2.1.8
      ) . EC:5.2.1.8 (UniProtKB | ENZYME | Rhea)
    • Rotamase SurA

Gene names

    • Name
      surA
    • Ordered locus names
      SPA0093

Organism names

Accessions

  • Primary accession
    Q5PDE6

Proteomes

Subcellular Location

Periplasm
Note: Is capable of associating with the outer membrane.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_000027003521-428Chaperone SurA

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain171-272PpiC 1
Domain282-382PpiC 2

Domain

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    428
  • Mass (Da)
    47,251
  • Last updated
    2005-01-04 v1
  • Checksum
    E85BA3468C81E3C8
MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAGQAGQQLPDDATLRHQILERLIMDQIILQMGQKMGVKITDEQLDQAIANIAKQNNMTMDQMRSRLAYDGLNYSTYRNQIRKEMIISEVRNNEVRRRITVLPQEVDALAKQIGTQNDASTELNLSHILIALPENPTSEQVNDAQRQAESIVEEARNGADFGKLAITYSADQQALKGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGQSQSISVTEVHARHILLKPSPIMNDQQARLKLEEIAADIKSGKTTFAAAAKEYSQDPGSANQGGDLGWATPDIFDPAFRDALTKLHKGQISAPVHSSFGWHLIELLDTRKVDKTDAAQKDRAYRMLMNRKFSEEAATWMQEQRASAYVKILSN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000026
EMBL· GenBank· DDBJ
AAV76126.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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